To investigate the effect of balneotherapy on body mass index, adipokine levels, sleep disturbances, and quality of life in women with morbid obesity. Fifty-four women with morbid obesity were included in the study. The body mass indexes (BMI) and waist/hip ratios (WHR) of the women were calculated. Subcutaneous fat thickness was measured using a *skinfold meter, and the percentage of adipose tissue was calculated. The *Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality, and the Nottingham Health Profile (NHP) was used to assess quality of life. In addition to routine biochemical tests, leptin, adipokine, visfatin from blood, and cortisol from saliva samples were studied. Participants were given 15 sessions of balneotherapy for 20 min each. After treatment, the laboratory and clinical parameters of the participants were *reevaluated. There was no statistically significant difference of BMI, WHR, and percentage of adipose tissue between before and after treatment measurements ( p ˃ 0.05).There was a statistically significant improvement in PSQI and NSP scores ( p ˂ 0.001). The levels of blood glucose, leptin, and visfatin were significantly decreased, and adiponectin was significantly increased after treatment ( p = 0.047, p ˂ 0.001, p ˂ 0.001, and p ˂ 0.001, respectively).There was no statistically significant changes in salivary cortisol levels ( p = 0.848). Patients with diabetes showed a statistically significant decrease in glucose levels after treatment ( p = 0.017).There was a statistically significant decrease in low-density lipoprotein cholesterol levels in patients with dyslipidemia compared with pre-treatment ( p = 0.018). Balneotherapy improves sleep and quality of life of women with morbid obesity. After balneotherapy, glucose, leptin, adiponectin, and visfatin levels may change positively.

中文翻译：

---

浴疗法对病态肥胖女性体重指数、脂肪因子水平、睡眠障碍和生活质量的影响

研究浴疗法对病态肥胖女性的体重指数、脂肪因子水平、睡眠障碍和生活质量的影响。该研究包括 54 名患有病态肥胖的女性。计算女性的体重指数（BMI）和腰臀比（WHR）。使用*skinfold仪测量皮下脂肪厚度，并计算脂肪组织的百分比。*匹兹堡睡眠质量指数（PSQI）用于评估睡眠质量，诺丁汉健康概况（NHP）用于评估生活质量。除了常规生化测试外，还研究了瘦素、脂肪因子、血液中的内脂素和唾液样本中的皮质醇。参与者接受了 15 次浴疗，每次 20 分钟。治疗后，*重新评估了参与者的实验室和临床参数。治疗前后BMI、WHR和脂肪组织百分比的差异无统计学意义（p˃0.05）。PSQI和NSP评分有统计学意义的改善（p˂0.001）。治疗后血糖、瘦素、内脂素水平显着降低，脂联素显着升高（分别为p = 0.047、p˂0.001、p˂0.001和p˂0.001）。唾液中无统计学意义的变化皮质醇水平 (p = 0.848)。糖尿病患者治疗后血糖水平显着降低（p = 0.017）。与治疗前相比，血脂异常患者的低密度脂蛋白胆固醇水平显着降低（p = 0.018）。浴疗法改善病态肥胖女性的睡眠和生活质量。浴疗法后，葡萄糖、瘦素、脂联素和内脂素水平可能会发生积极变化。