To develop bioactive and interactive wound-dressing materials based on natural products, poly(vinyl alcohol) (PVA) nanofibrous membranes containing plant-derived essential oils were fabricated and their potential applications for wound dressing were examined. Since essential oils, particularly palmarosa oil and phytoncide oil, possess natural antimicrobial and anti-inflammatory properties and are ecofriendly, they were chosen as bioactive agents to be incorporated into the nanofiber matrix. Antimicrobial efficacy, air/moisture vapor transport, and water uptake properties of the composite membranes were assessed to find suitable processing conditions for effective wound care. Palmarosa oil or phytoncide oil was incorporated into the core of PVA nanofibers via emulsion electrospinning. The PVA-based composite nanofibrous membranes were heat-treated to increase their stability in aqueous environments. Qualitative and quantitative antimicrobial assessments showed that the membranes containing palmarosa oil possessed superior antimicrobial effects against Staphylococcus aureus and Candida albicans over the membranes containing phytoncide oil. Air/moisture vapor transport and water uptake properties were assessed for the PVA-based composite membranes having two levels of web area density to find suitable conditions for creating an optimal wound-healing environment. The composite nanofibrous membranes, which had a web area density of 3 g/m2, provided reasonable levels of gas and moisture vapor permeability for effective wound care and possessed water uptake ability to allow exudate absorption. These results demonstrate that the electrospun core/sheath structured PVA nanofibrous membranes containing palmarosa oil have high potential as bioactive wound-dressing materials.

为了开发基于天然产物的生物活性和交互式伤口敷料，制备了含有植物精油的聚乙烯醇（PVA）纳米纤维膜，并研究了其在伤口敷料中的潜在应用。由于香精油，特别是棕榈油和植物杀菌素油，具有天然的抗菌和抗炎特性，并且对环境友好，因此被选作要掺入纳米纤维基质中的生物活性剂。评估了复合膜的抗菌功效，空气/水分蒸气传输和吸水特性，以找到合适的加工条件进行有效的伤口护理。通过乳液静电纺丝将Palmarosa油或phytoncide油掺入PVA纳米纤维的芯中。对PVA基复合纳米纤维膜进行热处理，以提高其在水性环境中的稳定性。定性和定量的抗菌评估表明，含棕榈油的膜具有优异的抗菌作用金黄色葡萄球菌和白色念珠菌在含有植物杀菌剂油的膜上。对于具有两个水平的网状区域密度的基于PVA的复合膜，评估了空气/水分的蒸气输送和吸水特性，以找到合适的条件以产生最佳的伤口愈合环境。复合纳米纤维膜的纤维网密度为3 g / m2，可提供合理水平的气体和湿气渗透性，以实现有效的伤口护理，并具有吸水能力，可吸收渗出液。这些结果表明，包含棕榈油的电纺芯/鞘结构的PVA纳米纤维膜具有很高的生物活性创面材料的潜力。