Fabrication of nanofibrous scaffolds of biodegradable polymers provides a great premise for several biological applications. In this study, nanofibrous polycaprolactone (PCL) mats incorporating Fe-MOF (PCL/x%Fe-MOF, x=5, 10, 20) were fabricated by electrospinning technique. The Fe-MOFs were separately synthesized by the hydrothermal method and then were added to PCL solution for preparation of nanofibrous composites. The presence of Fe-MOF in the fibers was demonstrated by various methods including FT-IR (Fourier-transform infrared), PXRD (powder X-ray diffraction), EDS (energy dispersive X-ray spectroscopy) mapping, SEM (scanning electron microscope), and TEM (transmission electron microscope). In the FT-IR spectra of the nanocomposites, the characteristic bands for the pure PCL and Fe-MOF showed no significant change in their positions, suggesting a weak chemical interaction with each other, although they physically mixed uniformly. Nanofibrous structure of the as-prepared nanocomposites was confirmed by SEM and TEM images. The diameter of PCL nanofibers was measured to be 369 nm. Biological investigations indicated that the experimented scaffolds including PCL/5%Fe-MOF and PCL/10%Fe-MOF nanofibrous scaffolds provided appropriate surface and mechanical properties such as cellular biocompatibility, high porosity, chemical stability, and optimum fiber diameter for cell adhesion, viability, and proliferation compared with PCL and PCL/20%Fe-MOF nanocomposites. Indeed, our results demonstrated that percent of Fe-MOF in the composites played a significant role in cell attachment and viability. Also, according to the implantation studies, up to at least 4 weeks, none of the animals showed any inflammatory response. Totally, we can be claimed that the modified electrospun scaffolds have been developed for tissue engineering applications.

可生物降解聚合物的纳米纤维支架的制造为多种生物学应用提供了一个很好的前提。在这项研究中，通过静电纺丝技术制备了掺有Fe-MOF的纳米纤维聚己内酯（PCL）垫（PCL / x％Fe-MOF，x = 5、10、20）。通过水热法分别合成Fe-MOF，然后将其添加到PCL溶液中以制备纳米纤维复合材料。通过多种方法证明了纤维中Fe-MOF的存在，包括FT-IR（傅立叶变换红外），PXRD（粉末X射线衍射），EDS（能量色散X射线光谱）映射，SEM（扫描电子显微镜） ）和TEM（透射电子显微镜）。在纳米复合材料的FT-IR光谱中，纯PCL和Fe-MOF的特征谱带未显示其位置的明显变化，尽管它们在物理上均匀混合，但彼此之间的化学相互作用较弱。通过SEM和TEM图像证实了所制备的纳米复合材料的纳米纤维结构。PCL纳米纤维的直径经测量为369nm。生物学研究表明，包括PCL / 5％Fe-MOF和PCL / 10％Fe-MOF纳米纤维支架在内的实验支架提供了适当的表面和机械性能，例如细胞生物相容性，高孔隙率，化学稳定性以及用于细胞粘附的最佳纤维直径，与PCL和PCL / 20％Fe-MOF纳米复合材料相比，具有更高的活力和增殖能力。实际上，我们的结果表明，复合物中Fe-MOF的百分比在细胞附着和生存能力中起着重要作用。另外，根据植入研究，至少要持续4周，没有动物表现出任何炎症反应。总的来说，我们可以说修饰的电纺支架是为组织工程应用开发的。