Two new sulfur compounds, designated thioporidiol A (1) and B (2), were discovered by the MoS-screening program from a culture broth of Trichoderma polypori FKI-7382. The structures of 1 and 2 were determined as C13 lipid structures with an N-acetylcysteine moiety. The relative configuration at the C-5 and C-6 position of 1 was determined by the derivatives of -methoxy--phenylacetic acid diesters, and the absolute configuration of the N-acetylcysteine moiety was determined by advanced Marfey's analysis. Compounds 1 and 2 were evaluated for anti-microbial, cytotoxic and anti-malarial activities. Compound 2 exhibited anti-microbial activity against Candida albicans ATCC 64548.

中文翻译：

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硫代二醇A和B：通过多孔木霉FKI-7382的钼催化氧化筛选发现的两种新的硫化合物。

通过MoS筛选程序，从多孢木霉FKI-7382的培养液中发现了两种新的硫化合物，分别为硫代孢子二醇A（1）和B（2）。1和2的结构确定为具有N-乙酰半胱氨酸部分的C13脂质结构。通过α-甲氧基-β-苯基乙酸二酯的衍生物确定在1的C-5和C-6位置的相对构型，并且通过先进的Marfey分析确定N-乙酰基半胱氨酸部分的绝对构型。评价化合物1和2的抗微生物，细胞毒性和抗疟活性。化合物2对白色念珠菌ATCC 64548表现出抗微生物活性。