Sestrins (Sesns) represent a highly conserved family of stress-inducing proteins that are involved in antioxidant and autophagy regulatory functions. They are very important mediators as they can protect the cells under a variety of noxious stimulating conditions. However, the functions of Sesns in aging has not yet been fully understood. Here, we summarize the roles of Sesns in the aging process. A series of studies have shown that Sesns are highly involved in the aging process by regulating the nutritional perception, metabolic homeostasis, immunity, autophagy, lifespan and health span. The details of how Sesns act on them will be described in this review. Due to the conservation of their function during evolution, Sesns may be used as novel targets for aging intervention and also provide new strategies for anti-aging treatment.

中文翻译：

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Sestrins 在调节衰老过程中的作用。

Sestrins (Sesns) 是一个高度保守的应激诱导蛋白家族，参与抗氧化和自噬调节功能。它们是非常重要的介质，因为它们可以在各种有害刺激条件下保护细胞。然而，Sesns 在衰老中的功能尚未完全了解。在这里，我们总结了 Sesns 在老化过程中的作用。一系列研究表明，Sesns 通过调节营养感知、代谢稳态、免疫、自噬、寿命和健康跨度，高度参与衰老过程。本评论将详细介绍 Sesns 如何对它们起作用。由于在进化过程中保留了它们的功能，Sesns 可以作为衰老干预的新靶点，也为抗衰老治疗提供新的策略。