Language processing relies on both a functionally specialized language network and a domain-general cognitive control network. Yet, how the two networks reorganize after damage resulting from diffuse and progressive glioma remains largely unknown. To address this issue, 130 patients with left cerebral gliomas, including 77 patients with low-grade glioma (LGG, WHO grade Ⅰ/II), 53 patients with high-grade glioma (HGG, WHO grade III/IV) and 38 healthy controls (HC) were adopted. The changes in resting-state functional connectivity (rsFC) of the language network and the cingulo-opercular/fronto-parietal (CO-FP) network were examined using network-based statistics. We found that tumor grade negatively correlated with language scores and language network integrity. Compared with HCs, patients with LGGs exhibited slight language deficits, both decreased and increased changes in rsFC of language network, and nearly normal CO-FP network. Patients with HGGs had significantly lower language scores than those with LGG and exhibited more severe language and CO-FP network disruptions than HCs or patients with LGGs. Moreover, we found that in patients with HGGs, the decreased rsFCs of language network were positively correlated with language scores. Together, our findings suggest tumor grade-related network reorganization of both language and control networks underlie the different levels of language impairments observed in patients with gliomas.

语言处理依赖于功能上专用的语言网络和领域通用的认知控制网络。然而，在弥散性和进行性神经胶质瘤造成的损伤后，这两个网络如何重组仍然是未知的。为解决这一问题，左脑神经胶质瘤患者130例，其中低度脑胶质瘤77例（LGG，WHOⅠ/ II级），53例高度脑胶质瘤（HGG，WHO III / IV级）和38名健康对照者（HC）被采用。使用基于网络的统计数据检查了语言网络和扣带-舌/额顶（CO-FP）网络的静态功能连接（rsFC）的变化。我们发现，肿瘤等级与语言得分和语言网络完整性呈负相关。与HCs相比，LGGs的患者语言表现较轻，语言网络的rsFC和接近正常的CO-FP网络的rsFC的变化都减少和增加。HGG患者的语言得分明显低于LGG患者，并且比HC或LGG患者表现出更严重的语言和CO-FP网络中断。此外，我们发现在患有HGGs的患者中，语言网络的rsFC减少与语言得分呈正相关。总之，我们的发现表明，与神经胶质瘤患者所观察到的语言障碍程度不同，这是语言和对照网络的肿瘤分级相关网络重组的基础。HGG患者的语言得分明显低于LGG患者，并且比HC或LGG患者表现出更严重的语言和CO-FP网络中断。此外，我们发现在患有HGGs的患者中，语言网络的rsFC减少与语言得分呈正相关。总之，我们的发现表明，与神经胶质瘤患者所观察到的语言障碍水平不同，这是语言和对照网络的肿瘤分级相关网络重组的基础。HGG患者的语言得分明显低于LGG患者，并且比HC或LGG患者表现出更严重的语言和CO-FP网络中断。此外，我们发现在患有HGGs的患者中，语言网络的rsFC减少与语言得分呈正相关。总之，我们的发现表明，与神经胶质瘤患者所观察到的语言障碍水平不同，这是语言和对照网络的肿瘤分级相关网络重组的基础。