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Bisabolane sesquiterpenes from the leaves of Lindera benzoin reduce prostaglandin E2 formation in A549 cells
Phytochemistry Letters ( IF 1.3 ) Pub Date : 2020-05-07 , DOI: 10.1016/j.phytol.2020.04.015
Astrid Henz Ryen , Thomas Göls , Julia Steinmetz , Ammar Tahir , Per-Johan Jakobsson , Anders Backlund , Ernst Urban , Sabine Glasl

Phytochemical investigation of leaves from the American shrub Lindera benzoin (L.) Blume (Lauraceae) resulted in the isolation of one pure compound 1 and a diastereomeric mixture of 2 and 3. The structures of these new bisabolane sesquiterpenes were elucidated via MS and extensive NMR measurements and identified as 6-(2-hydroxy-6-methylhept-5-en-2-yl)-3-(hydroxymethyl)-4-oxocyclohex-2-en-1-yl acetate (1) and 3-(hydroxymethyl)-6-(5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl)-4-oxocyclohex-2-en-1-yl acetate (2 and 3). The compounds were evaluated in vitro for their anti-inflammatory activity. In cellular assays, 1-3 reduced pro-inflammatory prostaglandin E2 production in A549 cells in a dose-dependent manner.



中文翻译:

从叶Bisabolane倍半萜乌药安息香降低A549细胞前列腺素E2的形成

对美国灌木Lindera benzoin(L.)Blume(Lauraceae)叶片的植物化学研究导致分离出一种纯化合物1以及23的非对映异构混合物。通过MS和广泛的NMR测量阐明了这些新的双五倍烷倍半萜的结构,并将其鉴定为6-(2-羟基-6-甲基庚-5-烯-2-基)-3-(羟甲基)-4-氧代环己基-2-乙酸烯-1-酯(1)和3-(羟甲基)-6-(5-(2-羟基丙-2-基)-2-甲基四氢呋喃-2-基)-4-氧代环己基-2-烯-1-乙酸乙烯酯(23)。在体外评估化合物的抗炎活性。在细胞试验,1 -3以剂量依赖的方式减少了A549细胞中炎性前列腺素E2的产生。

更新日期:2020-05-07
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