Phytochemical investigation of leaves from the American shrub Lindera benzoin (L.) Blume (Lauraceae) resulted in the isolation of one pure compound 1 and a diastereomeric mixture of 2 and 3. The structures of these new bisabolane sesquiterpenes were elucidated via MS and extensive NMR measurements and identified as 6-(2-hydroxy-6-methylhept-5-en-2-yl)-3-(hydroxymethyl)-4-oxocyclohex-2-en-1-yl acetate (1) and 3-(hydroxymethyl)-6-(5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl)-4-oxocyclohex-2-en-1-yl acetate (2 and 3). The compounds were evaluated in vitro for their anti-inflammatory activity. In cellular assays, 1-3 reduced pro-inflammatory prostaglandin E2 production in A549 cells in a dose-dependent manner.

对美国灌木Lindera benzoin（L.）Blume（Lauraceae）叶片的植物化学研究导致分离出一种纯化合物1以及2和3的非对映异构混合物。通过MS和广泛的NMR测量阐明了这些新的双五倍烷倍半萜的结构，并将其鉴定为6-（2-羟基-6-甲基庚-5-烯-2-基）-3-（羟甲基）-4-氧代环己基-2-乙酸烯-1-酯（1）和3-（羟甲基）-6-（5-（2-羟基丙-2-基）-2-甲基四氢呋喃-2-基）-4-氧代环己基-2-烯-1-乙酸乙烯酯（2和3）。在体外评估化合物的抗炎活性。在细胞试验，1 -3以剂量依赖的方式减少了A549细胞中炎性前列腺素E2的产生。