Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder. Epidemiological studies suggest that the exposure of the herbicide glyphosate may influence the development of PD in humans. In this study, we examined whether the exposure of glyphosate can affect the reduction of dopamine transporter (DAT) in the striatum and tyrosine hydroxylase (TH) in the substantial nigra (SNr) of mouse brain after repeated administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Repeated injections of MPTP (10 mg/kg × 3, 2-h interval) significantly decreased the density of DAT-immunoreactivity in the striatum and the number of TH-immunoreactivity in the SNr. Glyphosate exposure for 14 days significantly potentiated MPTP-induced dopaminergic neurotoxicity in the striatum and SNr of mouse brain. This study suggests that glyphosate exposure might exacerbate MPTP-induced dopaminergic neurotoxicity in the striatum and SNr of adult mice. It is likely that exposure of glyphosate may be an environmental risk factor for PD since glyphosate has been used widely in the world.

中文翻译：

---

重复施用 MPTP 后，草甘膦暴露会加剧小鼠大脑中的多巴胺能神经毒性。


帕金森病（PD）是一种慢性进行性神经退行性疾病。流行病学研究表明，接触除草剂草甘膦可能会影响人类帕金森病的发生。在本研究中，我们检测了重复施用1-甲基-4-后，草甘膦的暴露是否会影响小鼠大脑纹状体中的多巴胺转运蛋白（DAT）和黑质（SNr）中的酪氨酸羟化酶（TH）的减少。苯基-1,2,3,6-四氢吡啶（MPTP）。重复注射MPTP（10 mg/kg × 3，间隔2小时）显着降低纹状体中DAT免疫反应性密度和SNr中TH免疫反应性数量。草甘膦暴露 14 天显着增强了 MPTP 诱导的小鼠大脑纹状体和 SNr 中的多巴胺能神经毒性。这项研究表明，草甘膦暴露可能会加剧成年小鼠纹状体和 SNr 中 MPTP 诱导的多巴胺能神经毒性。由于草甘膦已在世界范围内广泛使用，因此接触草甘膦可能是帕金森病的环境风险因素。