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Problems and Pitfalls of Identifying Remyelination in Multiple Sclerosis.
Cell Stem Cell ( IF 19.8 ) Pub Date : 2020-05-07 , DOI: 10.1016/j.stem.2020.03.017
Bjoern Neumann 1 , Sarah Foerster 1 , Chao Zhao 1 , Benedetta Bodini 2 , Daniel S Reich 3 , Dwight E Bergles 4 , Ragnhildur Thóra Káradóttir 1 , Catherine Lubetzki 2 , Luke L Lairson 5 , Bernard Zalc 2 , Bruno Stankoff 2 , Robin J M Franklin 1
Affiliation  

Regenerative medicines that promote remyelination in multiple sclerosis (MS) are making the transition from laboratory to clinical trials. While animal models provide the experimental flexibility to analyze mechanisms of remyelination, here we discuss the challenges in understanding where and how remyelination occurs in MS.

中文翻译:

在多发性硬化症中识别髓鞘再生的问题和陷阱。

促进多发性硬化症(MS)中髓鞘再生的再生药物正在从实验室过渡到临床试验。尽管动物模型为分析髓鞘再生的机制提供了实验上的灵活性,但在这里我们讨论了理解MS中髓鞘再生的位置和方式所面临的挑战。
更新日期:2020-05-07
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