The current systematic review and meta-analysis of randomized controlled trials (RTCs) was conducted to summarize the effect of ginger supplementation on biomarkers of inflammation and oxidative stress in adults. Electronic databases including PubMed, Scopus, Web of Science, Cochrane Library and Google Scholar were systematically searched up to February 2018 to identify eligible RCTs which assessed the effect of ginger on C-reactive protein (CRP), interleukin-6 (IL-6) tumor necrosis factor (TNF-α), total antioxidant capacity (TAC) and lipid peroxidation products like malondialdehyde (MDA). Fourteen studies were eligible to be included in the quantitative analysis. Results from meta-analysis suggested that CRP (−0.8 mg/L, 95 % CI: −1.17 to −0.43; I² = 53 %), IL-6 (−2.26 pg/mL; 95 % CI: −4.00 to −0.52; I² = 58 %) and TNF-α (−1.33 pg/mL; 95 % CI: −1.85 to −0.80; I² = 55%) were significantly reduced by ginger supplementation. The pooled effect size indicated a significant increase in blood TAC levels after ginger consumption (1.26 μmol/L; 95 % CI: 0.17–2.35; I² = 84%). Ginger had no significant effect on MDA (−0.29 μmol/L; 95 % CI: −1.06 to 0.47; I² =78%). Subgroup analysis showed that the effect of ginger on CRP and TNF-α is more pronounced in studies with >80-days’ intervention. When studies were categorized based on hs-CRP/CRP, the effect of ginger was significant in both subgroups. In conclusion, the present study suggested that supplementation with ginger can improve health status in adults by lowering inflammatory and oxidative stress markers. Future trials with high methodological quality are needed to support the beneficial potential (anti-inflammatory and antioxidant effects) of ginger.

目前进行的随机对照试验（RTC）的系统综述和荟萃分析总结了生姜补充剂对成人炎症和氧化应激生物标志物的影响。截至2018年2月，系统搜索了包括PubMed，Scopus，Web of Science，Cochrane Library和Google Scholar在内的电子数据库，以鉴定符合条件的RCT，以评估姜对C反应蛋白（CRP），白介素6（IL-6）的影响。肿瘤坏死因子（TNF-α），总抗氧化能力（TAC）和脂质过氧化产物，如丙二醛（MDA）。十四项研究符合纳入定量分析的条件。荟萃分析的结果表明CRP（-0.8 mg / L，95％CI：-1.17至-0.43; I ²= 53％），IL-6（-2.26 pg / mL; 95％CI：-4.00至-0.52; I ² = 58％）和TNF-α（-1.33 pg / mL; 95％CI：-1.85至- 0.80; I ² = 55％）通过补充生姜明显减少。合并的效应量表明食用生姜后血液中的TAC水平显着增加（1.26μmol/ L； 95％CI：0.17–2.35；I ² = 84％）。生姜对MDA无明显影响（-0.29μmol/ L; 95％CI：-1.06至0.47; I ² = 78 ％）。亚组分析显示，在干预> 80天的研究中，生姜对CRP和TNF-α的影响更为明显。根据hs-CRP / CRP对研究进行分类时，姜在两个亚组中的作用均显着。总之，本研究表明，补充生姜可以降低炎症和氧化应激指标，从而改善成年人的健康状况。需要更高方法学质量的未来试验来支持姜的有益潜力（抗炎和抗氧化作用）。