Ethanamizuril is a new triazine compound that shows potential for application in novel anticoccidial treatment. In this study, a pharmacokinetic model of ethanamizuril was established on the basis of the blood concentration of 81 experimental animals. The final model showed that ethanamizuril was distributed as a two‐compartment model with first‐order absorption after oral administration in chickens. Its clearance rate and volumn of central compartment distribution (V _c) were affected by age and body weight, and volumn of central compartment distribution (V _c) and volume of peripheral compartment distribution(V _p) were influenced by weight and infection. External verification revealed that the model had good prediction accuracy and stability.

中文翻译：

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超高效液相色谱-串联质谱在正常和球虫感染的鸡中乙胺嘧啶的群体药代动力学。

乙胺嘧啶是一种新的三嗪化合物，显示出在新型抗球虫治疗中的应用潜力。在这项研究中，以81只实验动物的血药浓度为基础，建立了乙胺嘧啶的药代动力学模型。最终模型显示乙胺嘧啶以两室模型分布，口服后在鸡中具有一级吸收。其清除率和中央隔室分布的体积（V _c）受年龄和体重的影响，中央隔室分布的体积（V _c）和周围隔室的分布体积（V _p））受到体重和感染的影响。外部验证表明该模型具有良好的预测准确性和稳定性。