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A General Strategy to Encapsulate Semiconducting Polymers within PEGylated Mesoporous Silica Nanoparticles for Optical Imaging and Drug Delivery
Particle & Particle Systems Characterization ( IF 2.7 ) Pub Date : 2020-05-05 , DOI: 10.1002/ppsc.201900483 Feng Lu 1 , Chen Zhan 1 , Yi Gong 1 , Yufu Tang 1 , Chen Xie 1 , Qi Wang 1 , Wenjun Wang 2 , Quli Fan 1 , Wei Huang 3
Particle & Particle Systems Characterization ( IF 2.7 ) Pub Date : 2020-05-05 , DOI: 10.1002/ppsc.201900483 Feng Lu 1 , Chen Zhan 1 , Yi Gong 1 , Yufu Tang 1 , Chen Xie 1 , Qi Wang 1 , Wenjun Wang 2 , Quli Fan 1 , Wei Huang 3
Affiliation
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Although semiconducting polymers (SPs) have become an important category for optical imaging and phototherapy, their biomedical application is still facing a number of challenges. Herein, a cationic surfactant–assisted approach to encapsulate hydrophobic SPs within highly PEGylated mesoporous silica (mSiO2) nanoparticles with excellent colloidal stability and enhanced fluorescence in aqueous solution is reported. In comparison to the previously reported amphiphilic polymer coating and silification method, this universal strategy not only suppresses the formation of empty polymer micelles and free silica nanoparticles, but also provides high specific surface area for drug loading. As a proof of concept, furan‐containing diketopyrrolopyrrole‐based semiconducting polymers (PDFT) are coated with mesoporous silica and utilized for fluorescence imaging in the second near‐infrared region (NIR‐II, 1000–1700 nm) and drug delivery. In vivo blood vessel imaging and tumor imaging are achieved with high resolution (0.21 mm) and signal‐to‐background ratio (≈4.2). Additionally, pH‐responsive drug release and improved therapeutic effect are observed. By choosing desired SPs, different optical imaging and therapeutic modalities can also be achieved, thus the SP@mSiO2 nanostructures obtained here provide numerous opportunities for theranostic applications.
中文翻译：
将半导体聚合物封装在聚乙二醇化介孔二氧化硅纳米粒子中以进行光学成像和药物递送的一般策略
尽管半导体聚合物（SP）已成为光学成像和光疗的重要类别，但其生物医学应用仍面临许多挑战。本文采用阳离子表面活性剂辅助的方法将疏水性SP包封在高度PEG化的介孔二氧化硅（mSiO 2报道了具有优异的胶体稳定性和在水溶液中增强的荧光的纳米颗粒。与以前报道的两亲性聚合物涂层和硅化方法相比，这种通用策略不仅抑制了空的聚合物胶束和游离二氧化硅纳米颗粒的形成，而且还为载药提供了高比表面积。作为概念验证，将含呋喃的基于二酮吡咯并吡咯的半导体聚合物（PDFT）涂以中孔二氧化硅，并用于第二近红外区域（NIR-II，1000-1700 nm）的荧光成像和药物递送。高分辨率（0.21 mm）和信噪比（≈4.2）实现了体内血管成像和肿瘤成像。此外，观察到pH响应药物释放和改善的治疗效果。此处获得的2种纳米结构为医疗应用提供了许多机会。
更新日期：2020-05-05
中文翻译：
将半导体聚合物封装在聚乙二醇化介孔二氧化硅纳米粒子中以进行光学成像和药物递送的一般策略
尽管半导体聚合物（SP）已成为光学成像和光疗的重要类别，但其生物医学应用仍面临许多挑战。本文采用阳离子表面活性剂辅助的方法将疏水性SP包封在高度PEG化的介孔二氧化硅（mSiO 2报道了具有优异的胶体稳定性和在水溶液中增强的荧光的纳米颗粒。与以前报道的两亲性聚合物涂层和硅化方法相比，这种通用策略不仅抑制了空的聚合物胶束和游离二氧化硅纳米颗粒的形成，而且还为载药提供了高比表面积。作为概念验证，将含呋喃的基于二酮吡咯并吡咯的半导体聚合物（PDFT）涂以中孔二氧化硅，并用于第二近红外区域（NIR-II，1000-1700 nm）的荧光成像和药物递送。高分辨率（0.21 mm）和信噪比（≈4.2）实现了体内血管成像和肿瘤成像。此外，观察到pH响应药物释放和改善的治疗效果。此处获得的2种纳米结构为医疗应用提供了许多机会。
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