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Blood and tissue levels of lncRNAs in periodontitis.
Journal of Cellular Physiology ( IF 4.5 ) Pub Date : 2020-05-05 , DOI: 10.1002/jcp.29764 Arezou Sayad 1 , Soudeh Ghafouri-Fard 2 , Bahareh Shams 3 , Shahram Arsang-Jang 4 , Leila Gholami 5 , Mohammad Taheri 6
Journal of Cellular Physiology ( IF 4.5 ) Pub Date : 2020-05-05 , DOI: 10.1002/jcp.29764 Arezou Sayad 1 , Soudeh Ghafouri-Fard 2 , Bahareh Shams 3 , Shahram Arsang-Jang 4 , Leila Gholami 5 , Mohammad Taheri 6
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Periodontitis is a complex disorder that affects a large number of human beings from different ethnic groups. This condition has been associated with dysregulation of a number of genes, among them are long noncoding RNAs (lncRNAs). In the current study, we assessed the expression of four lncRNAs (BDNF‐AS, MIAT, MIR137HG, and PNKY) as well as BDNF in the peripheral blood and gingival tissues obtained from patients with periodontitis and healthy subjects. The expression of BDNF was significantly lower in blood samples of male patients with periodontitis compared with male controls (posterior β of RE = −4.754, p = .048). However, there was no significant difference in the expression of BDNF in tissue samples from the cases and controls. The expression of BDNF‐AS was significantly lower in the tissue samples of patients compared with control tissue samples (posterior β of RE = −2.151, p = .019). Such an expression difference was detected between male subgroups as well (posterior β of RE = −3.679, p = .009). However, expression of this lncRNA was not different in blood samples obtained from patients compared with healthy subjects. The expression of PNKY was significantly higher in tissue samples obtained from female patients compared with sex‐matched controls (posterior β of RE = 6.23, p = .037). Blood levels of this lncRNA were not different between cases and controls. There was no significant difference either in the tissue expression or in blood expression of MIR137HG or MIAT between cases and controls. The current study indicates the putative role of BDNF, BDNF‐AS, and PNKY in the pathophysiology of periodontitis and potentiates these genes as candidates for functional studies.
中文翻译：
牙周炎中lncRNA的血液和组织水平。
牙周炎是一种复杂的疾病，会影响许多来自不同种族的人。这种情况与许多基因的失调有关，其中包括长的非编码RNA（lncRNA）。在当前的研究中，我们评估了四种lncRNA（BDNF‐AS，MIAT，MIR137HG和PNKY）以及BDNF在牙周炎患者和健康受试者的外周血和牙龈组织中的表达。与男性对照组相比，男性牙周炎患者血液样本中BDNF的表达显着降低（RE的后β = -4.754，p = .048）。然而，在病例和对照的组织样品中BDNF的表达没有显着差异 。与对照组织样品相比，患者组织样品中BDNF‐AS的表达明显降低（RE的后β = = 2.151，p = .019）。在男性亚组之间也检测到这种表达差异（RE的后β = -3.679，p = .009 ）。然而，与健康受试者相比，从患者获得的血液样品中该lncRNA的表达没有差异。PNKY的表达与性别匹配的对照组相比，女性患者的组织样本中的组织样本明显更高（RE的后β = 6.23，p = .037）。病例和对照组之间该lncRNA的血液水平没有差异。病例与对照之间的MIR137HG或MIAT的组织表达或血液表达均无显着差异。本研究表明BDNF，BDNF‐AS和PNKY在牙周炎的病理生理中具有假定的作用，并将这些基因增强为功能性研究的候选基因。
更新日期：2020-05-05
中文翻译：
牙周炎中lncRNA的血液和组织水平。
牙周炎是一种复杂的疾病，会影响许多来自不同种族的人。这种情况与许多基因的失调有关，其中包括长的非编码RNA（lncRNA）。在当前的研究中，我们评估了四种lncRNA（BDNF‐AS，MIAT，MIR137HG和PNKY）以及BDNF在牙周炎患者和健康受试者的外周血和牙龈组织中的表达。与男性对照组相比，男性牙周炎患者血液样本中BDNF的表达显着降低（RE的后β = -4.754，p = .048）。然而，在病例和对照的组织样品中BDNF的表达没有显着差异 。与对照组织样品相比，患者组织样品中BDNF‐AS的表达明显降低（RE的后β = = 2.151，p = .019）。在男性亚组之间也检测到这种表达差异（RE的后β = -3.679，p = .009 ）。然而，与健康受试者相比，从患者获得的血液样品中该lncRNA的表达没有差异。PNKY的表达与性别匹配的对照组相比，女性患者的组织样本中的组织样本明显更高（RE的后β = 6.23，p = .037）。病例和对照组之间该lncRNA的血液水平没有差异。病例与对照之间的MIR137HG或MIAT的组织表达或血液表达均无显着差异。本研究表明BDNF，BDNF‐AS和PNKY在牙周炎的病理生理中具有假定的作用，并将这些基因增强为功能性研究的候选基因。
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