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Cytotoxic Meroterpenoids from the Sponge‐Associated Fungus Alternaria sp. JJY‐32
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2020-07-01 , DOI: 10.1002/cbdv.202000226 Lu Wang 1 , Jieying Jiao 2 , Dan Liu 1 , Xiaomin Zhang 1 , Jing Li 1 , Qian Che 1 , Tianjiao Zhu 1 , Guojian Zhang 1, 3 , Dehai Li 1, 3
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2020-07-01 , DOI: 10.1002/cbdv.202000226 Lu Wang 1 , Jieying Jiao 2 , Dan Liu 1 , Xiaomin Zhang 1 , Jing Li 1 , Qian Che 1 , Tianjiao Zhu 1 , Guojian Zhang 1, 3 , Dehai Li 1, 3
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Two new meroterpenoids, tricycloalternarenes X and Y, together with one known meroterpenoid, tricycloalternarene I, were isolated from the fungus Alternaria sp. JJY‐32. The structures including absolute configurations were established by the comprehensive spectroscopic data, electronic circular dichroism (ECD) spectral analyses, and biosynthesis consideration. Tricycloalternarene X showed cytotoxicity against the HL‐60 and HO8910 cells with IC50 values of 7.54 and 20.32 μm.
中文翻译：
来自海绵相关真菌链格孢属的细胞毒性类萜。JJY-32
从真菌 Alternaria sp. 中分离出两种新的类萜，tricycloalternarenes X 和 Y，以及一种已知的类萜，tricycloalternarene I。JJY-32。包括绝对构型在内的结构是通过综合光谱数据、电子圆二色性 (ECD) 光谱分析和生物合成考虑建立的。Tricycloalternarene X 对 HL-60 和 HO8910 细胞显示出细胞毒性，IC50 值为 7.54 和 20.32 μm。
更新日期：2020-07-01
中文翻译：
来自海绵相关真菌链格孢属的细胞毒性类萜。JJY-32
从真菌 Alternaria sp. 中分离出两种新的类萜，tricycloalternarenes X 和 Y，以及一种已知的类萜，tricycloalternarene I。JJY-32。包括绝对构型在内的结构是通过综合光谱数据、电子圆二色性 (ECD) 光谱分析和生物合成考虑建立的。Tricycloalternarene X 对 HL-60 和 HO8910 细胞显示出细胞毒性，IC50 值为 7.54 和 20.32 μm。
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