Objectives: FOSL1 is overexpressed in multiple cancers including malignant glioma and contributes to different cellular processes. However, little attention has been paid to the lower grade glioma (LGG).Methods: Cox coefficients were examined to compare FOSL1 expression among different tumors types using OncoLnc. The UCSC Xena browser was used to generate Kaplan-Meier survival curves and explore the association between FOSL1 expression and overall survival (OS) in TCGA-LGG and subgroups.Results: FOSL1 expression in LGG was ranked first among 21 different cancers. LGG with lower FOSL1 expression had longer OS (P < 0.001). The astrocytoma group had the highest FOSL1 expression and shortest OS, followed by oligoastrocytoma and oligodendroglioma (P < 0.05). The 1p19q co-deletion or IDH mutation subgroups had lower FOSL1 expression and longer OS (P < 0.001). Compared with the corresponding groups, LGG with lower FOSL1 expression had longer OS than the following groups: astrocytoma, oligodendroglioma, with/without 1p19q co-deletion, with IDH mutation, with radiation, and with pharmaceutical therapy (P < 0.05).Discussion: FOSL1 is a prognostic marker in LGG and subgroups.

中文翻译：

---

FOSL1的低表达与低级神经胶质瘤的良好预后和对放射/药物治疗的敏感性有关。

目的：FOSL1在包括恶性神经胶质瘤在内的多种癌症中过表达，并且参与了不同的细胞过程。然而，对低级神经胶质瘤（LGG）的关注却很少。方法：使用OncoLnc检测Cox系数以比较不同类型肿瘤之间的FOSL1表达。UCSC Xena浏览器用于生成Kaplan-Meier生存曲线，并探讨TCGA-LGG和亚组中FOSL1表达与总生存（OS）之间的关系。结果：LGG中FOSL1表达在21种不同的癌症中排名第一。FOSL1表达较低的LGG的OS较长（P <0.001）。星形细胞瘤组的FOSL1表达最高，OS最短，其次是星形胶质细胞瘤和少突胶质细胞瘤（P <0.05）。1p19q共缺失或IDH突变亚组具有较低的FOSL1表达和较长的OS（P <0.001）。与相应的组相比，FOSL1表达较低的LGG的OS比以下组更长：星形细胞瘤，少突胶质细胞瘤，有/无1p19q共缺失，IDH突变，有放射和药物治疗（P <0.05）。 FOSL1是LGG和亚组的预后标志物。