This study aimed to evaluate the memory function in a rat model of fatty liver and to investigate the effects of statins on fatty liver, neuronal inflammation, oxidative stress and memory. In this study, 24 male rats were used and were divided into four groups consisting of 6 animals in each. Of them, 12 rats received liquid diet containing 35% fructose for 8 weeks in order to induce hepatosteatosis, while other animals had a normal nutrition. Group 1 served as controls and had a normal nutrition with no drug treatment. The animals in Group 2 had a normal nutrition and treated with atorvastatin. Group 3 received high-fructose diet with no drug treatment and Group 4 received high-fructose diet followed by atorvastatin treatment. After the two weeks of treatment period, passive avoidance tasks evaluating the memory were performed in both the study and control groups. The liver and brain were then removed for histologic, pathologic, and biochemical evaluation. In the non-treated rats with hepatosteatosis (Group 3), the lowest mean latency time and the highest mean histopathologic liver score, and brain TNF- α and MDA (Measurement of lipid peroxidation) were found (p < 0.00001). On the other hand, in the animals treated with atorvastatin, all these parameters were significantly higher than that of controls and significantly lower than that of Group 3 (p < 0.05). Fatty liver can increase inflammation and cause memory disorders, and atorvastatin may have a positive effect on cognitive disorders.

中文翻译：

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阿托伐他汀可能通过其抗氧化和抗炎特性，具有治疗脂肪肝所致大鼠记忆功能障碍的潜力。

这项研究旨在评估大鼠脂肪肝的记忆功能，并研究他汀类药物对脂肪肝，神经元炎症，氧化应激和记忆的影响。在这项研究中，使用了24只雄性大鼠，将其分为4组，每组6只动物。其中，有12只大鼠接受了35％果糖的流质饮食，持续8周，以诱导肝脂肪变性，而其他动物则具有正常的营养。第一组作为对照组，营养正常，无需药物治疗。第2组的动物营养正常，并用阿托伐他汀治疗。第3组接受高果糖饮食，无需药物治疗，第4组接受高果糖饮食，然后接受阿托伐他汀治疗。经过两周的治疗后，在研究组和对照组中均进行了评估记忆的被动回避任务。然后取出肝脏和大脑进行组织学，病理学和生化评估。在未经治疗的肝脂肪变性大鼠（第3组）中，发现平均潜伏时间最短，平均组织病理学肝得分最高，脑TNF-α和MDA（脂质过氧化测定）（p <0.00001）。另一方面，在用阿托伐他汀治疗的动物中，所有这些参数均显着高于对照组，且显着低于第3组（p <0.05）。脂肪肝可增加炎症并引起记忆障碍，阿托伐他汀可能对认知障碍有积极作用。在未经治疗的肝脂肪变性大鼠（第3组）中，发现平均潜伏时间最短，平均组织病理学肝得分最高，脑TNF-α和MDA（脂质过氧化测定）（p <0.00001）。另一方面，在用阿托伐他汀治疗的动物中，所有这些参数均显着高于对照组，且显着低于第3组（p <0.05）。脂肪肝会增加炎症并引起记忆障碍，阿托伐他汀可能对认知障碍有积极作用。在未经治疗的肝脂肪变性大鼠（第3组）中，发现平均潜伏时间最短，平均组织病理学肝得分最高，脑TNF-α和MDA（脂质过氧化测定）（p <0.00001）。另一方面，在用阿托伐他汀治疗的动物中，所有这些参数均显着高于对照组，且显着低于第3组（p <0.05）。脂肪肝可增加炎症并引起记忆障碍，阿托伐他汀可能对认知障碍有积极作用。所有这些参数均显着高于对照组，且显着低于第3组（p <0.05）。脂肪肝会增加炎症并引起记忆障碍，而阿托伐他汀可能对认知障碍有积极作用。所有这些参数均显着高于对照组，且显着低于第3组（p <0.05）。脂肪肝会增加炎症并引起记忆障碍，而阿托伐他汀可能对认知障碍有积极作用。