Endodontic disease, a biofilm infection of the root canal space, is a significant cause of dental morbidity worldwide. Endodontic treatment, or root canal treatment, as it is commonly known is founded on the ability to eradicate microbial biofilm infection and prevent re-infection of the highly complex root canal space. Despite many "advances" in clinical endodontics we have seen little improvement in outcomes. The aim of this critical review paper is to provide a contemporary view of endodontic microbiology and biofilm polymicrobiality, provide an understanding of the host response, and how together these impact upon clinical treatment. Ultimately, it is intended to provide insight into novel opportunities and strategies for the future diagnostics, treatment, and prevention of endodontic disease.

中文翻译：

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牙髓生物膜感染的检测，治疗和预防：2020年有何新变化？

牙髓疾病是根管间隙的生物膜感染，是全世界牙科发病率的重要原因。如众所周知的，牙髓治疗或根管治疗建立在根除微生物生物膜感染并防止高度复杂的根管间隙再次感染的能力上。尽管临床牙髓治疗有许多“先进性”，但我们仍未见到效果改善。这篇重要评论文章的目的是提供牙髓微生物学和生物膜多微生物性的当代观点，了解宿主反应，以及这些因素如何共同影响临床治疗。最终，它旨在为牙髓病的未来诊断，治疗和预防提供新的机会和策略的见识。