Bacteria live in a polymicrobial community where it interacts with biotic and abiotic factors using specific signalling molecules. Acyl homoserine lactones, autoinducing peptides, bacteriocins and polyamines are a few signals documented for interspecies signalling. The signalling system could be used for a coordinated behaviour categorised as Quorum sensing (QS). QS is a term used to define a cell - cell communication process amongst bacteria that helps to gather cell density information and regulate gene expression accordingly. QS had been demonstrated to play a pivotal role in bacterial pathogenesis by regulating the expression of different virulence factors affecting adhesion, invasion and survival within a tissue. In the current review, we discuss the role of interspecies bacterial communication in pathogenicity. The molecules involved in the interspecies bacterial communication affecting virulence factors required for the establishment of infection have been discussed in detail to gain an insight for development of strategies that can be proposed to combat bacterial infections by attenuating their communication systems. The knowledge on the role of interspecies bacterial communication on virulence will assist in understanding the factors affecting symptomatic and asymptomatic infections.

中文翻译：

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种间细菌交流在致病菌毒性中的作用。

细菌生活在一个微生物群落中，在该群落中，细菌会使用特定的信号分子与生物和非生物因子相互作用。酰基高丝氨酸内酯，自诱导肽，细菌素和多胺是种间信号传递的一些信号。信令系统可用于分类为群体感应（QS）的协调行为。QS是用于定义细菌之间的细胞-细胞通讯过程的术语，有助于收集细胞密度信息并相应地调节基因表达。通过调节影响组织内粘附，侵袭和存活的不同毒力因子的表达，已证明QS在细菌发病机理中起关键作用。在当前的审查中，我们讨论种间细菌交流在致病性中的作用。已经详细讨论了涉及种间细菌传播的分子，这些分子影响建立感染所需的毒力因子，从而为开发可通过减弱其传播系统来抵抗细菌感染的策略的开发获得见识。关于种间细菌传播对毒力的作用的了解将有助于理解影响有症状和无症状感染的因素。