To quantitatively assess the distribution pattern of hippocampal tau pathology in Alzheimer's disease (AD) and primary age-related tauopathy (PART), we investigated the distribution of phosphorylated tau protein (AT8) in 6 anatomically defined subregions of the hippocampal formation and developed a mathematical algorithm to compare the patterns of tau deposition in PART and AD. We demonstrated regional patterns of selective vulnerability as distinguishing features of PART and AD in functionally relevant structures of the hippocampus. In AD cases, tau pathology was high in both CA1 and subiculum, followed by CA2/3, entorhinal cortex (EC), CA4, and dentate gyrus (DG). In PART, the severity of tau pathology in CA1 and subiculum was high, followed by EC, CA2/3, CA4, and DG. There are significant differences between sector DG and CA1, DG and subiculum in both AD and PART.

中文翻译：

---

AD 和 PART 中海马 Tau 病理学的定量评估。

为了定量评估阿尔茨海默病 (AD) 和原发性年龄相关 tau 病变 (PART) 中海马 tau 病理学的分布模式，我们研究了磷酸化 tau 蛋白 (AT8) 在海马形成的 6 个解剖学定义的亚区域中的分布，并开发了一个数学模型比较 PART 和 AD 中 tau 沉积模式的算法。我们展示了选择性脆弱性的区域模式作为海马功能相关结构中 PART 和 AD 的显着特征。在 AD 病例中，tau 病理学在 CA1 和下托中均较高，其次是 CA2/3、内嗅皮层 (EC)、CA4 和齿状回 (DG)。在 PART 中，CA1 和下托的 tau 病理严重程度高，其次是 EC、CA2/3、CA4 和 DG。DG 和 CA1 部门之间存在显着差异，