A metal-free C-N bond cleavage of amide functionality has been reported for the efficient and rapid synthesis of thioester in a simple flow system. The feasibility of this method has been investigated with various aliphatic and aromatic thiols with N-acylamide derivatives to deliver the corresponding thioesters. The fruitful outcome of this process includes good to excellent yields, broad functional group compatibility and can afford the thioesters in just 40 s.

Graphical abstract

中文翻译：

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连续流动是通过选择性CN键裂解合成硫酯的良性策略

据报道，酰胺官能团的无金属CN键裂解可在简单的流动系统中快速有效地合成硫酯。已经用各种脂族和芳族硫醇与N-酰基酰胺衍生物一起研究了该方法的可行性，以递送相应的硫酯。该过程的卓有成效的结果包括良好的收率，优异的收率，广泛的官能团相容性，并能在40秒内得到硫酯。

图形概要