The novel coronavirus disease (COVID-19) pandemic is placing significant strains on health systems, scientific communities, essential public services, and economies all over the world. In this context, the world´s scientific biomedical establishment is unleashing an unprecedented response to the COVID-19 pandemic. This is a battle against time, considering the thousands of human lives are lost every day. In this commentary, based on a very recent research report, we intend to highlight how a new mechanism describing the RAGE transactivation produced by Ang II-mediated ATR1 activation can run continuously and thus, reinforcing a sustained inflammation in lungs, due to the SARS-Cov-2-mediated imbalance of the ACE/And II/ATR1 pathway.

新型冠状病毒病（COVID-19）大流行给世界各地的卫生系统、科学界、基本公共服务和经济带来了巨大压力。在此背景下，世界科学生物医学机构正在对 COVID-19 大流行采取前所未有的应对措施。考虑到每天都有成千上万的人丧生，这是一场与时间的战斗。在这篇评论中，基于最近的一份研究报告，我们打算强调一种描述由 Ang II 介导的 ATR1 激活产生的 RAGE 反式激活的新机制如何能够持续运行，从而加强肺部的持续炎症，这是由于 SARS- Cov-2 介导的 ACE/And II/ATR1 通路失衡。