This study aimed to evaluate histological changes in targeted tilapia organs exposed to sublethal concentrations of carbofuran. Fishes with an average weight of 67.5 ± 2.0 g were exposed to sublethal concentrations (0.0044, 0.0088, 0.0440, and 0.0880 mg L⁻¹) of carbofuran for 7 days. In the end of the experiment, the gill, the liver, and the kidney samples were collected for histological evaluation. In gills exposed to 0.0044 mg L⁻¹ of carbofuran, an increase in interlayer epithelium and disruption of the secondary lamella was observed, while in other concentrations (0.0088, 0.0440, and 0.0880 mg L⁻¹), only blood congestion in the secondary lamellae occurred. In the liver samples of exposed tilapias, all carbofuran concentrations caused hepatocyte hypertrophy with the nuclei displaced to the cell periphery, stasis within the sinusoid capillaries, and necrosis points. All sublethal concentrations tested caused detachment of the glomerular capsule, necrosis in the proximal and distal tubules, and absence of intercellular space in the kidney of exposed tilapia. The presence of carbofuran in aquatic environments at concentrations from 0.0044 mg L⁻¹ and exposure periods longer than 7 days alters the gill, the liver, and the kidney histology and consequently compromising the fish’s health.

中文翻译：

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暴露于杀虫剂呋喃丹的亚致死浓度的尼罗罗非鱼（Oreochromis niloticus）靶向器官的组织学变化

这项研究旨在评估暴露于致死浓度的呋喃丹中的罗非鱼目标器官的组织学变化。将平均体重为67.5±2.0 g的鱼暴露于亚致命浓度（0.0044、0.0088、0.0440和0.0880 mg L ^-1）的呋喃丹中达7天。在实验结束时，收集ill，肝脏和肾脏样品进行组织学评估。在暴露于0.0044 mg L ^-1的呋喃丹中的ill中，观察到层间上皮增加和次级薄片破裂，而在其他浓度（0.0088、0.0440和0.0880 mg L ^-1中）），仅发生继发性片状细胞充血。在暴露的罗非鱼的肝脏样品中，所有的呋喃丹浓度均引起肝细胞肥大，细胞核移至细胞周围，血窦毛细血管内淤滞和坏死。测试的所有致死浓度均引起肾小球囊的分离，近端和远端小管坏死，以及暴露的罗非鱼肾脏中没有细胞间隙。在水生环境中浓度为0.0044 mg L ^-1的呋喃丹和暴露时间超过7天会改变the，肝脏和肾脏的组织学，从而损害鱼类的健康。