Continuous synthesis of nanoparticles in microreactors is enabled by their characteristic high mass and heat transfer rates with exquisite control of the synthetic parameters. However, their laminar regime present challenges such as tendency to clogging, broad residence time distributions and concentration profiles. Multi-phase systems (liquid–liquid, gas–liquid) overcome these issues by the creation of recirculation patterns between immiscible phases however, indirectly promotes particle–particle interaction, making necessary the addition of steric organic ligands to avoid agglomeration. Over the past few years, the design of the geometry of the reactors has been presented as an alternative approach to control the hydrodynamics in single-phase system. Secondary flows such as Dean vorteces within the laminar regime are promoted on coiled and helical reactors enhancing mass transfer and narrowing residence time distributions. This approach enables the synthesis of nanoparticles in the absence of organic surface ligands with narrow size distribution opening the door to size tuneability.

微反应器中纳米颗粒的连续合成是由于其特有的高质量和传热速率以及对合成参数的精确控制而实现的。然而，它们的层流状态提出了诸如堵塞趋势，宽的停留时间分布和浓度分布的挑战。多相系统（液-液，气-液）通过在不混溶相之间建立再循环模式克服了这些问题，但是间接地促进了颗粒间的相互作用，因此必须添加空间有机配体以避免团聚。在过去的几年中，已经提出了反应堆的几何设计作为控制单相系统中流体动力学的替代方法。层流状态下的二次流（例如迪安涡旋）在螺旋和螺旋反应器上得到促进，从而增强了传质并缩小了停留时间分布。该方法能够在不存在具有狭窄尺寸分布的有机表面配体的情况下合成纳米颗粒，这为尺寸可调性打开了大门。