We report the synthesis, photophysical characterization and kinetics of a series of polycyclic sydnone derivatives as a potential new class of fluorogenic clickable reagents. After strain-promoted cycloaddition with cyclooctyne BCN, the fluorescence generated by pyrazole products displayed up-to 115-fold fluorescence enhancement compared to reactants. These preliminary results are of interest for possible future applications in bioorthogonal chemistry.

中文翻译：

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基于多环sydnone支架的荧光探针

我们报告了一系列的多环sydnone衍生物作为潜在的新型荧光点击类试剂的合成，光物理特性和动力学。与环辛炔BCN应变促进的环加成反应后，与反应物相比，吡唑产物产生的荧光显示高达115倍的荧光增强。这些初步的结果对于未来在生物正交化学中的应用很有兴趣。