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Endometrial compaction before frozen euploid embryo transfer improves ongoing pregnancy rates
Fertility and Sterility ( IF 6.6 ) Pub Date : 2020-05-01 , DOI: 10.1016/j.fertnstert.2019.12.030
Eran Zilberberg 1 , Ramsey Smith 2 , Dan Nayot 2 , Jigal Haas 3 , James Meriano 2 , Eran Barzilay 4 , Robert F Casper 5
Affiliation  

OBJECTIVE To assess whether the calculated difference in endometrial thickness from the end of the estrogen phase to the day of ET (after 6 days of P in hormonally prepared cycles) is associated with ongoing pregnancy rates in euploid frozen ETs (FETs). DESIGN An observational cohort study. SETTING Single tertiary care medical center. PATIENT(S) Ultrasound images from 234 hormonally prepared FET cycles were assessed. All the transfers were elective single ETs of a euploid embryo, post-preimplantation genetic testing for aneuploidy (PGT-A). INTERVENTION(S) Ultrasound measurements of peak endometrial thickness at the end of the estrogen phase and again after 6 days of P at the time of ET. MAIN OUTCOME MEASURE(S) Ongoing pregnancy rate in relation to the delta between endometrial thickness at the end of estrogen phase and at the time of ET. RESULT(S) We calculated the ongoing pregnancy rate in cycles where the endometrial lining decreased (compacted) after addition of P by 5%, 10%, 15%, and 20% and demonstrated a significantly higher pregnancy rate after all rates of compaction of the endometrial lining in comparison with cycles where the endometrial lining did not compact. The ongoing pregnancy rate in this cohort, after compaction of 15% or more, was 51.5%, compared with 30.2% in cycles where the endometrial lining did not compact. CONCLUSION(S) There is a significant correlation between endometrial lining compaction and ongoing pregnancy rate in FET cycles of euploid embryos. These findings help to explain why some euploid embryos may fail to implant.

中文翻译:

冷冻整倍体胚胎移植前的子宫内膜压实可提高持续妊娠率

目的 评估从雌激素期结束到 ET 当天(在激素准备周期中 P 6 天后)计算出的子宫内膜厚度差异是否与整倍体冷冻 ET (FET) 的持续妊娠率相关。设计 一项观察性队列研究。设置单一的三级保健医疗中心。评估了来自 234 个激素制备的 FET 周期的患者的超声图像。所有转移都是整倍体胚胎的选择性单 ET,非整倍体的植入前基因检测 (PGT-A)。干预(S) 在雌激素期结束时和在 ET 时 P 6 天后再次测量峰值子宫内膜厚度的超声测量。主要结局指标 持续妊娠率与雌激素期末和 ET 时子宫内膜厚度之间的差值有关。结果 我们计算了在添加 P 5%、10%、15% 和 20% 后子宫内膜内层减少(压实)的周期中的持续妊娠率,并证明在所有压实率后妊娠率显着提高子宫内膜与子宫内膜不致密的周期相比。该队列中的持续妊娠率在 15% 或更多压实后为 51.5%,而在子宫内膜未压实的周期中为 30.2%。结论(S) 在整倍体胚胎的 FET 周期中,子宫内膜压实与持续妊娠率之间存在显着相关性。这些发现有助于解释为什么一些整倍体胚胎可能无法植入。10%、15% 和 20%,并且与子宫内膜未压实的周期相比,在子宫内膜所有压实率后显示出显着更高的妊娠率。该队列中的持续妊娠率在 15% 或更多压实后为 51.5%,而在子宫内膜未压实的周期中为 30.2%。结论(S) 在整倍体胚胎的 FET 周期中,子宫内膜压实与持续妊娠率之间存在显着相关性。这些发现有助于解释为什么一些整倍体胚胎可能无法植入。10%、15% 和 20%,并且与子宫内膜未压实的周期相比,在子宫内膜所有压实率后显示出显着更高的妊娠率。该队列中的持续妊娠率在 15% 或更多压实后为 51.5%,而在子宫内膜未压实的周期中为 30.2%。结论(S) 在整倍体胚胎的 FET 周期中,子宫内膜压实与持续妊娠率之间存在显着相关性。这些发现有助于解释为什么一些整倍体胚胎可能无法植入。压实 15% 或更多后,为 51.5%,而在子宫内膜未压实的周期中为 30.2%。结论(S) 在整倍体胚胎的 FET 周期中,子宫内膜压实与持续妊娠率之间存在显着相关性。这些发现有助于解释为什么一些整倍体胚胎可能无法植入。压实 15% 或更多后,为 51.5%,而在子宫内膜未压实的周期中为 30.2%。结论(S) 在整倍体胚胎的 FET 周期中,子宫内膜压实与持续妊娠率之间存在显着相关性。这些发现有助于解释为什么一些整倍体胚胎可能无法植入。
更新日期:2020-05-01
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