OBJECTIVE To study the development of children conceived from non-IVF infertility treatments consisting of gonadotropins, clomiphene, or letrozole. DESIGN Prospective cohort study. SETTING U.S. academic health centers. PATIENT(S) Children of women with polycystic ovary syndrome who conceived with letrozole (LTZ) or clomiphene (CC) in the PPCOS II study or women with unexplained infertility (AMIGOS study) who conceived with LTZ, CC, or gonadotropin (GN). INTERVENTION(S) Longitudinal annual follow-up from birth to age 3. MAIN OUTCOME MEASURE(S) Scores from Ages and Stages Developmental Questionnaire (ASQ), MacArthur-Bates Communicative Development Inventory (MCDI), and annual growth. RESULT(S) One hundred eighty-five children from 160 families participated in at least one follow-up evaluation from the two infertility trials. Most multiple gestations in the follow-up study resulted from GN treatment (n = 14) followed by CC (n = 6) and LTZ (n = 3). There were no significant differences among the three groups at any time point with respect to abnormal scores on the ASQ. On the MCDI Words and Gestures, the LTZ group scored significantly higher than the GN group for most items (phrases, early gestures, later gestures, and total gestures). Children in the CC group scored significantly higher than the GN group for the later gestures and total gestures items. CONCLUSION(S) Differences in growth and cognitive developmental rates among children conceived with first-line infertility therapies, including LTZ, are relatively minor and likely due to differences in multiple pregnancy rates.

中文翻译：

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妊娠登记：对使用来曲唑、克罗米芬或促性腺激素的孩子进行为期三年的随访

目的 研究由促性腺激素、克罗米芬或来曲唑组成的非试管婴儿不孕症治疗所孕育的儿童的发育。设计前瞻性队列研究。设立美国学术健康中心。患者 PPCOS II 研究中使用来曲唑 (LTZ) 或克罗米芬 (CC) 受孕的多囊卵巢综合征女性或使用 LTZ、CC 或促性腺激素 (GN) 受孕的不明原因不孕症（AMIGOS 研究）女性的孩子。干预措施 从出生到年龄的纵向年度随访 3. 主要结果测量 年龄和阶段发展问卷 (ASQ)、麦克阿瑟-贝茨交流发展量表 (MCDI) 和年度增长的分数。结果 来自 160 个家庭的 185 名儿童至少参加了两项不孕症试验的一项后续评估。后续研究中的大多数多胎妊娠由 GN 治疗（n = 14）引起，其次是 CC（n = 6）和 LTZ（n = 3）。在任何时间点，三组之间在 ASQ 异常分数方面没有显着差异。在 MCDI Words and Gestures 上，LTZ 组在大多数项目（短语、早期手势、后期手势和总手势）的得分明显高于 GN 组。CC组的孩子在后期的手势和总的手势项目上得分明显高于GN组。结论 (S) 接受包括 LTZ 在内的一线不孕症治疗的儿童在生长和认知发育率方面的差异相对较小，可能是由于多胎妊娠率的差异。