Background

Comorbidity between obsessive compulsive disorder (OCD) and psychotic disorders has long been a subject of interest and speculation, with much overlap being reported. The current review seeks to: (1) Investigate the prevalence of co-occurring OCD and psychosis, reporting pooled prevalence rates; and (2) Explore variability in reported rates on the basis of categorical and/or dimensional classifications of OCD and psychosis and (3) explore potential moderators of variability.

Method

A systematic search was performed of key databases (Embase, PSYCHInfo, MEDLINE, Scopus) from January 1988 to October 2017. Included in the meta-analyses were studies that reported adult (18+) prevalence of comorbid OCD, obsessional compulsive symptoms (OCS) and psychosis-related disorders.

Results

94 articles with 103 effect sizes were extracted. Overall, when using categorical diagnoses, the prevalence rate of comorbid OCD and psychotic disorder was 12% (n = 155649; k = 81; 95% CI = 9–15%). Using diagnostic plus symptom criteria, the prevalence was 24% (n = 9563; k = 46, 95% CI = 20–28%).

Conclusion

Given the substantial co-occurrence, it is important that individuals presenting in routine clinical practice are assessed for both disorders. To advance understanding, future research must go beyond comorbidity to explore latent dimensions that may account for their development and/or maintenance (e.g., trauma).

中文翻译：

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强迫症和精神病的合并症：系统评价和荟萃分析

背景

强迫症（OCD）和精神病之间的合并症长期以来一直是人们关注和猜测的话题，据报道有很多重叠之处。当前的审查旨在：（1）调查同时发生的强迫症和精神病的患病率，报告合并患病率；（2）根据强迫症和精神病的分类和/或维度分类，探讨报告率的变异性；（3）探索潜在的变异性调节剂。

方法

从1988年1月至2017年10月，对关键数据库（Embase，PSYCHInfo，MEDLINE，Scopus）进行了系统搜索。荟萃分析中包括报告成年人（18岁以上）合并强迫症，强迫症（OCS）患病率的研究。和精神病相关的疾病。

结果

提取94种效果大小为103的文章。总体而言，使用分类诊断时，合并性强迫症和精神病的患病率为12％（n = 155649； k = 81； 95％CI = 9-15％）。使用诊断加症状标准，患病率为24％（n = 9563； k = 46，95％CI = 20–28％）。

结论

鉴于大量同时发生，对常规临床实践中出现的个体进行两种疾病的评估很重要。为了加深理解，未来的研究必须超越合并症，以探索可能导致其发展和/或维持（例如创伤）的潜在因素。