The materials used in bone tissue engineering (BTE) have been advancing with each passing day. With the continuous development of nanomedicine, gold nanoparticles (GNPs), which are easy to be synthesized and functionalized, have attracted increasing attention. Recent years have witnessed this amazing material, i.e., GNPs characterized with large surface area to volume ratio, biocompatibility, medical imaging property, hypotoxicity, translocation into the cells, high reactivity, and other properties, perform distinct functions in BTE. However, the low stability of GNPs in the biotic environment makes them in the requirements of modification or recombination before being used. After being combined with the advantages of other materials, the structures of GNPs have exhibited great potential in stem cells, scaffolds, delivery systems, medical imaging, and other aspects. This review will focus on the advances in the application of GNPs after modification or recombination with other materials to BTE.

中文翻译：

---

金纳米粒子在骨组织工程中的应用进展。

骨组织工程（BTE）中使用的材料日新月异。随着纳米医学的不断发展，易于合成和功能化的金纳米颗粒（GNP）引起了越来越多的关注。近年来，已经见证了这种惊人的材料，即具有大的表面积与体积之比，生物相容性，医学成像特性，低毒性，易位进入细胞，高反应性和其他特性的GNP，在BTE中发挥着独特的功能。然而，GNP在生物环境中的低稳定性使其在使用前需要修饰或重组。结合其他材料的优势后，GNP的结构在干细胞，支架，递送系统，医学成像，和其他方面。这篇综述将侧重于将GNP应用于BTE或与其他材料修饰或重组后的应用进展。