RNA modifications are emerging as critical regulators in cancer biology, thanks to their ability to influence gene expression and the predominant protein isoforms expressed during cell proliferation, migration, and other pro-oncogenic properties. The reversibility and dynamic nature of post-transcriptional RNA modifications allow cells to quickly adapt to microenvironmental changes. Recent literature has revealed that the deregulation of RNA modifications can promote a plethora of developmental diseases, including tumorigenesis. In this review, we will focus on four key post-transcriptional RNA modifications which have been identified as contributors to the pathogenesis of brain tumors: m6A, alternative polyadenylation, alternative splicing and adenosine to inosine modifications. In addition to the role of RNA modifications in brain tumor progression, we will also discuss potential opportunities to target these processes to improve the dismal prognosis for brain tumors.

中文翻译：

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脑肿瘤发生中的RNA修饰。

RNA 修饰正在成为癌症生物学中的关键调节因子，因为它们能够影响基因表达以及细胞增殖、迁移和其他促癌特性期间表达的主要蛋白质亚型。转录后 RNA 修饰的可逆性和动态性质使细胞能够快速适应微环境变化。最近的文献表明，RNA 修饰的失调会促进多种发育疾病，包括肿瘤发生。在这篇综述中，我们将重点关注四个关键的转录后 RNA 修饰，这些修饰已被确定为脑肿瘤发病机制的贡献者：m6A、选择性多腺苷酸化、选择性剪接和腺苷至肌苷修饰。除了 RNA 修饰在脑肿瘤进展中的作用外，我们还将讨论针对这些过程的潜在机会，以改善脑肿瘤的不良预后。