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Recent Advances in Synthetic Methods for Radioiodination.
The Journal of Organic Chemistry ( IF 3.6 ) Pub Date : 2020-05-05 , DOI: 10.1021/acs.joc.0c00644
Emmanuelle Dubost 1 , Holly McErlain 2 , Victor Babin 1 , Andrew Sutherland 2 , Thomas Cailly 1, 3, 4
Affiliation  

Organic compounds bearing radioisotopes of iodine are widely used for biological research, diagnostic imaging, and radiotherapy. Early reported synthetic methods for the incorporation of radioiodine have generally involved high temperature reactions or strongly oxidizing conditions. To overcome these limitations and to cope with the demand for novel radioiodinated probes, there has been a surge in the development of new synthetic methodology for radioiodination. This synopsis describes the key transformations developed recently.

中文翻译:

放射性碘合成方法的最新进展。

带有碘放射性同位素的有机化合物被广泛用于生物学研究,诊断成像和放射治疗。早期报道的掺入放射性碘的合成方法通常涉及高温反应或强氧化条件。为了克服这些局限性并满足对新型放射性碘标记探针的需求,用于放射性碘标记的新的合成方法的发展已经激增。此提要描述了最近开发的关键转换。
更新日期:2020-07-02
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