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Cross-linked polydimethylsiloxane colloid as novel contrast agent for gastrointestinal magnetic resonance imaging: Transient nuclear Overhauser effect within the interface.
Journal of Biomaterials Applications ( IF 2.3 ) Pub Date : 2020-05-04 , DOI: 10.1177/0885328220921528
Fu-Hu Su 1, 2 , Wang-Chuan Xiao 1, 2 , Sheann-Huei Lin 1 , Qiyong Li 1, 2
Affiliation  

With good contrast in T1 and T2 weighted imaging as well as low toxicity in 3- (4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay, this work proposes the cross-linked polydimethylsiloxane colloids as a novel non-ionic contrast agent for gastrointestinal magnetic resonance imaging. The experiments of nuclear magnetic resonance spectra and relaxation show that within the interface of the colloids, there are nuclear Overhauser effect and transient nuclear Overhauser effect (cross-relaxation). Regarding the longitudinal relaxation experiments of CH2CH2O segments of Tween 80, a two spins system is found and modeled well by the equation IZI0= S0((1X) etD1 (1+X) etT1) which is deduced based on the transient nuclear Overhauser effect proposed by Solomon. The arbitrary constant X is additionally added with the initial conditions (Iz − I0)t=0 = −2XS0 and (Sz − S0)t=0 = −2S0. For the two spins system, D1 and T1 are corresponding to longitudinal relaxation times of the bound water and the CH2CH2O respectively. Concerning the transverse relaxation experiments of the CH2CH2O, they agree with the equation with three exponential decays, defined by three relaxation times, likely corresponding to three mechanisms. These mechanisms possibly are intramolecular and intermolecular dipole–dipole (DD) interactions and scalar coupling. Within the interface, hydrogen bonding causes the positive nuclear Overhauser effect of the CH2CH2O’s nuclear magnetic resonance spectra, the transient nuclear Overhauser effect of the CH2CH2O’s longitudinal relaxation experiments and the intermolecular dipole–dipole interactions of the CH2CH2O’s transverse relaxation experiments.



中文翻译:

交联聚二甲基硅氧烷胶体作为胃肠道磁共振成像的新型造影剂:界面内的瞬态核 Overhauser 效应。

凭借T 1T 2加权成像的良好对比度以及 3- (4,5-二甲基-2-噻唑基)-2,5-二苯基-2H-溴化四唑 (MTT) 测定的低毒性,这项工作提出了交联聚二甲基硅氧烷胶体作为胃肠道磁共振成像的新型非离子造影剂。核磁共振谱和弛豫实验表明,在胶体界面内,存在核Overhauser效应和瞬态核Overhauser效应(交叉弛豫)。关于吐温 80的 CH 2 CH 2 O 段的纵向弛豫实验,发现了一个双自旋系统,并通过方程很好地建模一世Z-一世0= 0((1-X) 电子-D1 -(1+X) 电子-1)这是根据所罗门提出的瞬态核奥弗豪泽效应推导出来的。任意常数X还与初始条件 ( I z  -  I 0 ) t =0  = -2 XS 0和 ( S z  -  S 0 ) t =0  = -2 S 0相加。对于两个自旋系统,D 1T 1分别对应结合水和CH 2 CH 2 的纵向弛豫时间分别为O。关于 CH 2 CH 2 O的横向弛豫实验,他们同意具有三个指数衰减的方程,由三个弛豫时间定义,可能对应于三种机制。这些机制可能是分子内和分子间偶极-偶极 (DD) 相互作用和标量耦合。内的接口,氢键使CH的正核Overhauser效应2 CH 2 O公司核磁共振谱,瞬态核Overhauser效应的CH 2 CH 2 O公司纵向弛豫实验和CH的分子间的偶极-偶极相互作用2通道2O 的横向弛豫实验。

更新日期:2020-07-13
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