Abstract

Beer is a source of folate, vitamin B₆ and B₁₂, molecules involved in the pathways of homocysteine (HCY), a risk factor for cardiovascular disease. This research evaluated if a consumption of craft or industrial beer could reduce serum HCY. In a randomised cross-over study, 12 men (28.7 ± 6.0 years) and 12 women (29.4 ± 7.5 years), healthy, omnivorous, with normal body mass index, non-smoking and not taking oral supplements or contraceptives, followed a free-living diet and received, daily, for 3 weeks, 330 ml of industrial (4.5% of alcohol) or craft beer (9% of alcohol). Anthropometric measures and blood samples were taken at the beginning and at the end of each period. The consumption of industrial beer reduced (p < 0.05) HCY (7.35 vs. 6.50 µmol/L) and increased folic acid (3.46 vs. 3.94 ng/mL). Craft beer increased gamma-gluamyl transpeptidase (GGT) (16.6 vs. 18.6 U/L) and reduced vitamin B₆ (20.9 vs. 16.9 ng/mL).

摘要

啤酒是叶酸，维生素B ₆和B ₁₂的来源，叶酸是高半胱氨酸（HCY）途径中的分子，而高半胱氨酸是心血管疾病的危险因素。这项研究评估了食用工艺啤酒或工业啤酒是否可以降低血清HCY。在一项随机交叉研究中，有12名男性（28.7±6.0岁）和12名女性（29.4±7.5岁），健康，杂食性，体重指数正常，禁烟，不服用口服补充剂或避孕药，随后免费-维持饮食，每天接受330毫升的工业饮料（酒精含量为4.5％）或精酿啤酒（酒精含量为9％），持续3周。在每个时期的开始和结束时都要进行人体测量和血液采样。工业啤酒的消耗减少（p <0.05）HCY（7.35对6.50 µmol / L）和增加的叶酸（3.46对3.94 ng / mL）。精酿啤酒增加了γ-谷氨酰转肽酶（GGT）（16.6 vs. 18.6 U / L）并降低了维生素B ₆（20.9 vs. 16.9 ng / mL）。