Mechanical forces are known to influence cellular processes with consequences at the cellular and physiological level. The cell nucleus is the largest and stiffest organelle, and it is connected to the cytoskeleton for proper cellular function. The connection between the nucleus and the cytoskeleton is in most cases mediated by the linker of nucleoskeleton and cytoskeleton (LINC) complex. Not surprisingly, the nucleus and the associated cytoskeleton are implicated in multiple mechanotransduction pathways important for cellular activities. Herein, we review recent advances describing how the LINC complex, the nuclear lamina, and nuclear pore complexes are involved in nuclear mechanotransduction. We will also discuss how the perinuclear actin cytoskeleton is important for the regulation of nuclear mechanotransduction. Additionally, we discuss the relevance of nuclear mechanotransduction for cell migration, development, and how nuclear mechanotransduction impairment leads to multiple disorders.

中文翻译：

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细胞核在机械转导中的作用。

已知机械力会影响细胞过程，并在细胞和生理水平产生影响。细胞核是最大，最坚硬的细胞器，它与细胞骨架相连以发挥适当的细胞功能。在大多数情况下，核与细胞骨架之间的连接是由核骨架和细胞骨架（LINC）复合物的接头介导的。毫不奇怪，细胞核和相关的细胞骨架与对细胞活动重要的多种机械转导途径有关。本文中，我们回顾了描述LINC复合物，核层和核孔复合物如何参与核机械转导的最新进展。我们还将讨论核周肌动蛋白细胞骨架对于调节核机械转导如何重要。另外，