Introduction

Cysticidal drugs have improved the prognosis of thousands of patients with neurocysticercosis (NCC). However, conflicting studies have created controversies on the actual value of these drugs. Here, the reasons of these controversies, as well as evidence showing the beneficial role of cysticidal drugs are reviewed.

Areas covered

The present review (based on different databases searches up to March 2020), focuses on the evidence supporting the use of cysticidal drugs in patients with NCC. For parenchymal NCC, albendazole alone must be used for patients with one or two cysts, while the combination of albendazole plus praziquantel is advised for those with more than two lesions. Level I evidence on the optimal regimens of cysticidal drugs for treatment of extraparenchymal NCC is lacking, although there is growing evidence supporting the use of cysticidal drugs in these cases, providing that hydrocephalus and intracranial hypertension have previously been treated.

Expert opinion

With the exception of therapy of patients with viable parenchymal brain cysticerci, we are far from getting level I evidence on the best approach for each of the other forms of NCC, as most of our knowledge on therapy for extraparenchymal NCC is based on non-controlled studies or small series of patients.

中文翻译：

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神经囊尾osis病的杀菌药物治疗的当前方法。

介绍

杀虫药已改善了成千上万的神经囊虫病（NCC）患者的预后。但是，相互矛盾的研究对这些药物的实际价值产生了争议。在此，回顾了这些争议的原因，以及显示出杀菌剂的有益作用的证据。

覆盖区域

本综述（基于截至2020年3月的不同数据库搜索），重点关注支持在NCC患者中使用杀菌剂的证据。对于实质性NCC，患有一个或两个囊肿的患者必须单独使用阿苯达唑，而对于具有两个以上病变的患者，建议联合使用阿苯达唑和吡喹酮。尽管有越来越多的证据支持在这种情况下使用杀虫药，但前提是先前已对脑积水和颅内高压进行了治疗，但目前尚缺乏有关最佳杀伤性药物用于治疗实质性NCC的最佳方案的I级证据。

专家意见

除了对可行的实质性脑囊虫的患者进行治疗以外，我们还远没有获得其他形式的NCC的最佳方法的I级证据，因为我们对实质性NCC的大多数治疗知识都是基于非控制性的。研究或少量患者。