Chlamydia trachomatis has a say on the target gene i.e., modulating the expression of target gene in the host so that it is given protection from the immune cells and so its survival and replication are not arrested by the host. The current study reports a wide range of C. trachomatis proteins that target the cellular as well as sub-cellular components of the host in gynecologic malignancy. Various bioinformatics tools was used to conduct an in-depth analysis on nuclear and eukaryotic sub cellular localization signal to find the sequences of the predicted proteins of C. trachomatis strain G. A total of 411 proteins was identified with 79.54% maximum expected accuracy and 51.02% least expected accuracy. There were uneven prediction of proteins along with redundancies between BaCeILo and HSLpred in the determination of sub-cellular localization of the CT proteins. The highest molecular weight proteins (>80 kDa) were observed to be the targeted proteins to nucleus of host cell. There was no constant patterns observed in the values of isoelectric point (pI) in case of mitochondrial targeting. The expression of eight proteins were significant with different fold changes. The in-silico study provided much detailed insights for further research in gynecological cancer. However, further experiments should be conducted to validate the specificity and confirmatory roles played by these predicted proteins in carcinogenesis.

中文翻译：

---

了解沙眼衣原体微生物发病机制及其在妇科恶性肿瘤中的意义的生物信息学方法。

沙眼衣原体对靶基因有发言权，即调节宿主中靶基因的表达，使其免受免疫细胞的侵害，因此其存活和复制不会被宿主阻止。目前的研究报告了广泛的沙眼衣原体蛋白质，这些蛋白质靶向妇科恶性肿瘤中宿主的细胞和亚细胞成分。利用多种生物信息学工具对核和真核亚细胞定位信号进行深入分析，找到沙眼衣原体菌株G预测蛋白的序列。共鉴定出411个蛋白，最大预期准确率79.54%，预测准确率51.02 % 最低预期准确度。在确定 CT 蛋白的亚细胞定位方面，BaCeILo 和 HSLpred 之间存在蛋白质预测不均匀以及冗余。观察到最高分子量的蛋白质（> 80 kDa）是宿主细胞核的靶向蛋白质。在线粒体靶向的情况下，等电点 (pI) 值没有观察到恒定模式。八种蛋白质的表达具有显着性，具有不同的倍数变化。计算机内研究为妇科癌症的进一步研究提供了非常详细的见解。然而，应该进行进一步的实验来验证这些预测的蛋白质在致癌作用中所起的特异性和确认作用。在线粒体靶向的情况下，等电点 (pI) 值没有观察到恒定模式。八种蛋白质的表达具有显着性，具有不同的倍数变化。计算机内研究为妇科癌症的进一步研究提供了非常详细的见解。然而，应该进行进一步的实验来验证这些预测的蛋白质在致癌作用中所起的特异性和确认作用。在线粒体靶向的情况下，等电点 (pI) 值没有观察到恒定模式。八种蛋白质的表达具有显着性，具有不同的倍数变化。计算机内研究为妇科癌症的进一步研究提供了非常详细的见解。然而，应该进行进一步的实验来验证这些预测的蛋白质在致癌作用中所起的特异性和确认作用。