ABSTRACT

Child malnutrition is a global public health challenge. A protein malnutrition (PM) model in young mice was established in this study. The efficacy of an ocean-based protein (APP) extracted from by-catch fish as compared to casein and soy on restoring body weight, bone growth, and immunity of PM mice was evaluated. Results show that supplementation of APP increases body weight, lean muscle mass, bone area, mineral content and density. APP supplementation increases spleen, thymus weight, and interlukin-6 production. In conclusion, APP is an alternative source of protein to effectively restore body weight, bone growth and immune function of PM mice.

摘要

儿童营养不良是全球公共卫生挑战。在这项研究中建立了年轻小鼠的蛋白质营养不良（PM）模型。评估了从副渔获鱼中提取的海洋蛋白（APP）与酪蛋白和大豆相比在恢复体重，骨骼生长和PM小鼠免疫力方面的功效。结果表明，补充APP可增加体重，瘦肌肉，骨骼面积，矿物质含量和密度。APP补充剂可增加脾脏，胸腺重量和白介素6的产生。总之，APP是有效恢复PM小鼠体重，骨骼生长和免疫功能的蛋白质的替代来源。