The objective of this experiment was to study and compare the effects of dietary supplementation of organic and inorganic zinc (Zn) on growth performance, nutrient utilisation and gene expression pattern of glucose transporter protein in peripheral blood mononuclear cells (PBMC) in Malabari kids. Fifteen, 3-4-month-old goat kids were divided into three groups uniformly by using completely randomised design (CRD). Group G1 was fed on basal diet as per NRC requirement, and G2 and G3 were fed on basal diet + 40 ppm Zn as inorganic zinc sulphate (ZnSO4) and 40 ppm Zn as organic Zn methionine, respectively, for a period of 91 days. Supplementation of inorganic and organic Zn had no significant effect on dry matter (DM) intake. The digestibility of crude protein (CP), ether extract (EE), neutral detergent fibre (NDF), hemicellulose and cellulose was significantly more in the organic Zn-supplemented group. The average daily gain and feed:gain ratio were significantly (p < 0.05) better in group G3 in comparison to G1 and G2, while the nitrogen retention was found to be (p < 0.01) higher in group G3 than in group G1. Zinc balance was found to be significantly (p < 0.01) increased in both supplemented groups with respect to unsupplemented group G1. The blood glucose level was (p < 0.01) lower in group G3 compared to group G1 suggesting the insulin-like activity of Zn. Serum Zn concentration was significantly (p < 0.01) increased in both Zn-supplemented groups. There was a significant (p < 0.05) rise in glucose transporter GLUT1 expression in groups G2 and G3 when compared to control group G1. Moreover, GLUT1 expression was found to be higher (p < 0.05) in group G3 as against the animals of group G2. Lowered blood glucose level might have stimulated more glucose transporter GLUT1 expression in PBMC. Organic Zn supplemented at 40 ppm level resulted in better growth performance, nutrient digestibility and nitrogen as well as Zn retention in goat kids. There was better absorption, and hence, less amount of Zn got excreted in the organic Zn-supplemented group.

中文翻译：

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无机和有机锌补充剂对马拉巴里儿童生长性能、矿物质分布和 GLUT1 基因表达模式的影响。

本实验的目的是研究和比较膳食补充有机和无机锌 (Zn) 对马拉巴里儿童外周血单核细胞 (PBMC) 生长性能、营养利用和葡萄糖转运蛋白基因表达模式的影响。采用完全随机设计（CRD）将 15 只 3-4 个月大的山羊孩子均匀地分为三组。G1 组按照 NRC 要求饲喂基础日粮，G2 和 G3 组分别饲喂基础日粮 + 40 ppm Zn 作为无机硫酸锌 (ZnSO4) 和 40 ppm Zn 作为有机甲硫氨酸锌，持续 91 天。补充无机和有机锌对干物质 (DM) 摄入量没有显着影响。粗蛋白（CP）、乙醚提取物（EE）、中性洗涤纤维（NDF）的消化率，半纤维素和纤维素在有机锌补充组中明显更多。与 G1 和 G2 相比，G3 组的平均日增重和饲料：增重比显着（p < 0.05）更好，而 G3 组的氮保留量（p < 0.01）高于 G1 组。与未补充组 G1 相比，两个补充组的锌平衡均显着增加（p < 0.01）。与 G1 组相比，G3 组的血糖水平 (p < 0.01) 较低，表明 Zn 具有胰岛素样活性。在两个锌补充组中，血清锌浓度显着增加（p < 0.01）。与对照组 G1 相比，G2 和 G3 组的葡萄糖转运蛋白 GLUT1 表达显着（p < 0.05）升高。而且，发现与 G2 组动物相比，G3 组中的 GLUT1 表达更高（p < 0.05）。降低的血糖水平可能刺激了 PBMC 中更多的葡萄糖转运蛋白 GLUT1 表达。添加 40 ppm 水平的有机锌可提高山羊孩子的生长性能、营养消化率和氮以及锌的保留率。有更好的吸收，因此，在有机锌补充组中排出的锌量较少。