We investigated the antifungal susceptibilities and the cyp51 mutant strains among Aspergillus fumigatus clinical isolates obtained from 10 university hospitals in Korea. Of the 84 isolates examined, two itraconazole-resistant isolates were found with no amino acid substitution in the cyp51A/cyp51B genes. However, 19 (23.2%) azole-susceptible isolates harbored amino acid substitutions: Nine isolates harbored one to five mutations in cyp51A with high polymorphism, and 11 isolates exhibited the same Q42L mutation in cyp51B. Overall, a low azole resistance rate and high frequency of cyp51A/cyp51B amino acid substitutions were observed in the azole-susceptible A. fumigatus isolates in Korea.

中文翻译：

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韩国多中心临床烟曲霉菌株中的抗真菌药敏试验和cyp51突变菌株。

我们调查了从韩国10所大学医院获得的烟曲霉临床分离株中的抗真菌药敏性和cyp51突变株。在所检查的84个分离株中，发现有2个对伊曲康唑耐药的分离株在cyp51A / cyp51B基因中没有氨基酸取代。但是，有19个（23.2％）对吡咯敏感的分离株具有氨基酸取代：9个分离株在cyp51A中具有1至5个具有高多态性的突变，而11个分离株在cyp51B中具有相同的Q42L突变。总体而言，在韩国对吡咯敏感的烟曲霉菌株中观察到了低的吡咯耐药率和cyp51A / cyp51B氨基酸置换的频率。