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Glomerular filtration rate: comparison of simultaneous plasma clearance of 99mTc-DTPA and 51Cr-EDTA revisited.
Scandinavian Journal of Clinical and Laboratory Investigation ( IF 1.3 ) Pub Date : 2020-05-02 , DOI: 10.1080/00365513.2020.1759138
Jane A Simonsen 1 , Kasper Thilsing-Hansen 1 , Poul F Høilund-Carlsen 1, 2 , Oke Gerke 1, 2 , Thomas L Andersen 1
Affiliation  

The issue of whether 99mTc-DTPA can replace 51Cr-EDTA for measurement of plasma clearance as a surrogate for glomerular filtration rate (GFR) is of great relevance to daily clinical practice. Prompted by the shortage of 51Cr-EDTA we conducted a head-to-head comparison in patients attending our department for GFR determination. The two tracers (3.7 MBq of 51Cr-EDTA and 8 MBq of 99mTc-DTPA) were administered intravenously immediately after each other, and the standard number of blood samples were drawn. Fifty-four patients were enrolled. In 51 of these, single-sample measurement was performed with the following results: GFREDTA was 84.6 ± 23.3 mL/min, GFRDTPA was 84.2 ± 24.7 mL/min. The mean difference was 0.4 ± 2.8 mL/min, p = 0.32, and results based on the two tracers were highly correlated (r = 0.995). GFRDTPA exceeded GFREDTA at high GFR values (difference < 0 at GFREDTA >91.4 mL/min) and vice versa (difference > 0 at GFREDTA < 91.4 mL/min). However, differences fell within few GFR units that most often will have no clinical consequence. We therefore conclude that 99mTc-DTPA can replace 51Cr-EDTA for single-sample determination of GFR in a clinical setting.



中文翻译:

肾小球滤过率:再次比较99mTc-DTPA和51Cr-EDTA的同时血浆清除率。

99m Tc-DTPA是否可以代替51 Cr-EDTA来测量血浆清除率,以此作为肾小球滤过率(GFR)的替代品,这一问题与日常临床实践密切相关。由于缺乏51 Cr-EDTA,我们对参加我们科室测定GFR的患者进行了正面对比。彼此立即静脉内施用两种示踪剂(3.7 MBq的51 Cr-EDTA和8 MBq的99m Tc-DTPA),并抽取标准数量的血样。入选了54例患者。在其中的51个样品中,单样品测量结果如下:GFR EDTA为84.6±23.3 mL / min,GFR DTPA为84.2±24.7mL / min。平均差异为0.4±2.8 mL / min,p  = 0.32,基于两种示踪剂的结果高度相关(r  = 0.995)。在高GFR值下(GFR EDTA > 91.4 mL / min时差值<0),GFR DTPA超过GFR EDTA,反之亦然(在GFR EDTA <91.4 mL / min时差值> 0 )。但是,差异落在几个GFR单位内,大多数情况下不会产生临床后果。因此,我们得出结论,在临床环境中,99m Tc-DTPA可以代替51 Cr-EDTA用于单样本测定GFR。

更新日期:2020-05-02
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