Neutrophilic dermatoses are a heterogeneous group of inflammatory skin disorders characterized by the presence of a sterile, predominantly neutrophilic infiltrate on histopathology. Universally accepted and validated guidelines for the management of neutrophilic dermatoses do not exist, also given the paucity of randomized controlled study and high-quality data. However, the literature on the effective use of biologic therapies is rapidly expanding. This article reviews the epidemiology, clinical characteristics, histopathologic features, and management of pyoderma gangrenosum as well as Sweet’s syndrome, sub-corneal pustular dermatoses and bowel-associated dermatosis arthritis syndrome. The use of biologic agents, including tumor necrosis factor α-inhibitors, anti-IL1, anti-IL-17, and IL-23 are discussed in detail.

中性粒细胞性皮肤病是炎性皮肤疾病的异质性组，其特征在于在组织病理学上存在无菌的，主要是中性粒细胞性浸润。考虑到随机对照研究和高质量数据的匮乏，中性粒细胞性皮肤病治疗的普遍接受和验证的指南还不存在。然而，关于有效使用生物疗法的文献正在迅速扩展。本文综述了坏疽性脓皮病以及Sweet氏综合症，角膜下脓疱性皮肤病和肠道相关性皮病关节炎综合症的流行病学，临床特征，组织病理学特征和治疗。详细讨论了生物制剂的使用，包括肿瘤坏死因子α抑制剂，抗IL1，抗IL-17和IL-23。