Compared to healthy pregnant women, changes in erythrocytic membrane anionic charge (EAC) and urinary glycosaminoglycans (U_GAGS) have been reported in African women with preeclampsia. A single previous study showed a decrease in erythrocytic membrane sialic acid (EMSA) in preeclampsia compared to healthy pregnancy; however, EMSA was not significantly different between women with preeclampsia and non-pregnant women. No study has focused on the relationships between EAC, EMSA, and U_GAGS in preeclampsia and eclampsia compared to healthy pregnant and non-pregnant women of reproductive age. Moreover, the erythrocyte membrane contains sialoglycoproteins and proteoglycans involved in creating the negatively charged cell surface, disruption of which leads to erythrocyte aggregation seen in preeclampsia/eclampsia. However, the etiopathogenesis of preeclampsia and eclampsia remains unclear. Therefore, we evaluated the relationship between EAC, U_GAGS, and EMSA in preeclampsia and eclampsia. Three groups of 30 women each were enrolled: Group A (non-pregnant women), Group B (healthy pregnant women without complications), and Group C (women with preeclampsia/eclampsia). EMSA was diminished under oxidative stress prevalent in eclampsia and preeclampsia which might have caused a decreased EAC. EAC was negatively correlated with U_GAGS and positively correlated with EMSA (p < .001). EMSA was negatively correlated with U_GAGS (p < .001). In conclusion, a loss of sialic acid from the erythrocyte membrane causes a significant decrease in the EAC which mirrors the decrease in the negative charge of the renal glomerular basement membrane and might lead to proteinuria and increased U_GAGS excretion in preeclampsia and eclampsia.

与健康孕妇相比，非洲先兆子痫妇女的红细胞膜阴离子电荷（EAC）和尿糖_胺聚糖（U _GAGS）的变化已有报道。一项先前的研究表明，与健康妊娠相比，先兆子痫患者的红细胞膜唾液酸（EMSA）降低。然而，子痫前期妇女和非妊娠妇女的EMSA没有显着差异。没有研究关注EAC，EMSA和U _GAGS之间的关系在子痫前期和子痫中的比例与健康的孕妇和未怀孕的育龄妇女相比。此外，红细胞膜含有唾液酸糖蛋白和蛋白聚糖，参与形成带负电荷的细胞表面，破坏其会导致先兆子痫/子痫中所见的红细胞聚集。然而，子痫前期和子痫的病因仍不清楚。因此，我们评估了EAC，U _GAGS之间的关系，以及子痫前期和子痫中的EMSA。分为三组，每组30名妇女：A组（非孕妇），B组（无并发症的健康孕妇）和C组（子痫前期/子痫的妇女）。在子痫和先兆子痫中普遍存在的氧化应激下，EMSA减少，这可能导致EAC降低。EAC与U _GAGS负相关，与EMSA正相关（p  <.001）。EMSA与U _GAGS呈负相关（p  <.001）。总之，唾液酸从红细胞膜中流失会导致EAC显着下降，这反映出肾小球基底膜负电荷的下降，并可能导致蛋白尿和U增高子痫前期和子痫的_GAGS排泄。