当前位置：
X-MOL 学术
›
Geroscience
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
SARS-CoV-2 and COVID-19 in older adults: what we may expect regarding pathogenesis, immune responses, and outcomes.
GeroScience ( IF 5.6 ) Pub Date : 2020-04-10 , DOI: 10.1007/s11357-020-00186-0 Janko Nikolich-Zugich 1, 2 , Kenneth S Knox 3, 4 , Carlos Tafich Rios 5 , Bhupinder Natt 3 , Deepta Bhattacharya 1 , Mindy J Fain 2, 5
GeroScience ( IF 5.6 ) Pub Date : 2020-04-10 , DOI: 10.1007/s11357-020-00186-0 Janko Nikolich-Zugich 1, 2 , Kenneth S Knox 3, 4 , Carlos Tafich Rios 5 , Bhupinder Natt 3 , Deepta Bhattacharya 1 , Mindy J Fain 2, 5
Affiliation
SARS-CoV-2 virus, the causative agent of the coronavirus infectious disease-19 (COVID-19), is taking the globe by storm, approaching 500,000 confirmed cases and over 21,000 deaths as of March 25, 2020. While under control in some affected Asian countries (Taiwan, Singapore, Vietnam), the virus demonstrated an exponential phase of infectivity in several large countries (China in late January and February and many European countries and the USA in March), with cases exploding by 30–50,000/day in the third and fourth weeks of March, 2020. SARS-CoV-2 has proven to be particularly deadly to older adults and those with certain underlying medical conditions, many of whom are of advanced age. Here, we briefly review the virus, its structure and evolution, epidemiology and pathogenesis, immunogenicity and immune, and clinical response in older adults, using available knowledge on SARS-CoV-2 and its highly pathogenic relatives MERS-CoV and SARS-CoV-1. We conclude by discussing clinical and basic science approaches to protect older adults against this disease.
更新日期：2020-04-10
京公网安备 11010802027423号