Our study aimed to investigate the effects of platelet-rich plasma (PRP) on impaired glucose homeostasis, disrupted islet insulin secretion, and pancreatic oxidative status in streptozotocin (STZ)-diabetic rats. A total of 64 Sprague-Dawley male were randomized to four groups including controls, diabetes, control-PRP, and diabetes-PRP. The rats received the PRP (0.5 ml/kg, SC injection) twice weekly for 4 weeks. Plasma glucose and insulin levels, pancreatic oxidative stress markers and islet insulin secretion and content were measured. Compared with the control group, in the diabetic group, increased plasma glucose and malondialdehyde (MDA) levels and decreased plasma insulin level, islet insulin secretion, pancreatic superoxide dismutase (SOD), and catalase activities were observed. PRP treatment significantly reduced plasma glucose and MDA levels and enhanced plasma insulin, antioxidant enzyme activity, islet insulin secretion, and content in the diabetic rats. These findings showed that PRP can improve pancreatic islet insulin secretion, pancreatic oxidative stress and regulate plasma insulin and glucose levels in diabetic rats.

我们的研究旨在探讨富含血小板的血浆（PRP）对链脲佐菌素（STZ）糖尿病大鼠葡萄糖稳态，受损的胰岛胰岛素分泌和胰腺氧化状态的影响。总共64位Sprague-Dawley男性被随机分为四组，包括对照组，糖尿病，对照组PRP和糖尿病PRP。大鼠每周两次接受PRP（0.5 ml / kg，SC注射），持续4周。测量血浆葡萄糖和胰岛素水平，胰腺氧化应激指标以及胰岛胰岛素分泌和含量。与对照组相比，在糖尿病组，增加的血浆葡萄糖和丙二醛（MDA）水平和降低血浆胰岛素水平，胰岛的胰岛素分泌，胰岛小号观察到过氧化物歧化酶（SOD）和过氧化氢酶活性。PRP治疗可显着降低血浆葡萄糖和MDA水平，并增强糖尿病大鼠的血浆胰岛素，抗氧化酶活性，胰岛胰岛素分泌和含量。这些发现表明，PRP可以改善糖尿病大鼠的胰岛胰岛素分泌，胰腺氧化应激并调节血浆胰岛素和葡萄糖水平。