Autophagy is defined as separation and degradation of cytoplasmic components through autophagosomes, which plays an essential part in physiological and pathological events. Hence it is also essential for cellular homeostasis. Autophagy disorder may bring about the failure of stem cells to maintain the fundamental transformation and metabolism of cell components. However, for cancer cells, the disorder of autophagy is a feasible antitumor idea. Nanoparticles, referring to particles of the size range 1-100 nanometers, are appearing as a category of autophagy regulators. These nanoparticles may revolutionize and broaden the therapeutic strategies of many diseases, including neurodegenerative diseases, tumors, muscle disease, and so on. Researches of autophagy-induced nanomaterials mainly focus on silver particles, gold particles, silicon particles, and rare earth oxides. But in recent years, more and more materials have been found to regulate autophagy, such as nano-nucleic acid materials, nanofiber scaffolds, quantum dots, and so on. The review highlights that various kinds of nanoparticles have the power to regulate autophagy intensity in stem cells of interest and further control biological behaviors, which may become a reliable treatment choice for disease therapy.

自噬被定义为通过自噬体分离和降解细胞质成分，其在生理和病理事件中起重要作用。因此，它对于细胞稳态也是必不可少的。自噬障碍可能导致干细胞无法维持细胞成分的基本转化和代谢。然而，对于癌细胞而言，自噬紊乱是一种可行的抗肿瘤思路。纳米颗粒是指尺寸范围在 1-100 纳米的颗粒，作为一类自噬调节剂出现。这些纳米粒子可能会彻底改变和拓宽许多疾病的治疗策略，包括神经退行性疾病、肿瘤、肌肉疾病等。自噬诱导纳米材料的研究主要集中在银颗粒、金颗粒、硅颗粒、和稀土氧化物。但近年来，越来越多的材料被发现可以调控自噬，如纳米核酸材料、纳米纤维支架、量子点等。该综述强调，各种纳米颗粒具有调节目标干细胞自噬强度并进一步控制生物学行为的能力，这可能成为疾病治疗的可靠治疗选择。