Background: Cardiovascular disease (CVD), including disorders of cardiac muscle and vascular, is the major cause of death globally. Many unsuccessful attempts have been made to intervene in the disease's pathogenesis and treatment. Stem cell-based therapies, as a regeneration strategy, cast a new hope for CVD treatment. One of the most well-known stem cells is mesenchymal stem cells (MSCs), classified as one of the adult stem cells and can be obtained from different tissues. These cells have superior properties, such as proliferation and highly specialized differentiation. On the other hand, they have the potential to modulate the immune system and anti-inflammatory activity. One of their most important features is the secreting the extracellular vesicles (EVs) like exosomes (EXOs) as an intercellular communication system mediating the different physiological and pathophysiological affairs.

Methods: In this review study, the importance of MSC and its secretory exosomes for the treatment of heart disease has been together and specifically addressed and the use of these promising natural and accessible agents is predicted to replace the current treatment modalities even faster than we imagine.

Results: MSC derived EXOs by providing a pro-regenerative condition allowing innate stem cells to repair damaged tissues successfully. As a result, MSCs are considered as the appropriate cellular source in regenerative medicine. In the plethora of experiments, MSCs and MSC-EXOs have been used for the treatment and regeneration of heart diseases and myocardial lesions.

Conclusion: Administration of MSCs has been provided a replacement therapeutic option for heart regeneration, obtaining great attention among the basic researcher and the medical doctors.

背景：心血管疾病（CVD），包括心肌和血管疾病，是全球范围内死亡的主要原因。已经进行了许多不成功的尝试来干预该疾病的发病机理和治疗。基于干细胞的疗法作为一种再生策略，为CVD治疗带来了新的希望。间充质干细胞（MSCs）是最著名的干细胞之一，被分类为成年干细胞之一，可以从不同的组织中获得。这些细胞具有优越的特性，例如增殖和高度专门化的分化。另一方面，它们具有调节免疫系统和抗炎活性的潜力。

方法：在这项综述性研究中，MSC及其分泌性外泌体在治疗心脏病中的重要性已被一起具体解决，并且预测这些有前途的天然药物和可及药物的使用将以比我们想象的更快的速度取代目前的治疗方式。

结果：MSC通过提供一种促进再生的条件衍生出EXO，允许先天干细胞成功修复受损组织。结果，MSC被认为是再生医学中合适的细胞来源。在大量的实验中，MSC和MSC-EXO被用于治疗和再生心脏病和心肌损伤。

结论：MSCs的给药已成为心脏再生的替代治疗选择，受到基础研究者和医生的广泛关注。