The treatment of pets, service animals, and pre-clinical research subjects with radionuclides raises concern for the safety of the people who interact with the animals after their treatment. Three treatments of skeletal conditions in dogs are considered in this study: Sm-1,4,7,10-tetraazacylcododecanetetramethylenephosphonic acid, which is a bone-seeking radiopharmaceutical; unencapsulated Y permanent interstitial implants, which are sometimes called "liquid brachytherapy"; and Sn radiosynoviorthesis, which is also called radiosynovectomy. External exposure rate readings of the Sm and Sn treatments, and Monte Carlo simulations of Sn at a distance of 1 m and of all three in direct contact with tissue were analyzed for doses. Dogs that have received any of these treatments using typically administered activities may be released from radiation safety isolation immediately after treatment from the standpoint of external exposure. People should avoid prolonged close proximity, such as sleeping with a treated dog, for three weeks following an Y interstitial implant or for a month following Sn radiosynoviorthesis. No such avoidance is necessary after treatment with Sm-1,4,7,10-tetraazacylcododecanetetramethylenephosphonic acid.

中文翻译：

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使用 153Sm、90Y 和 117mSn 治疗犬骨骼疾病时的辐射安全注意事项。


用放射性核素治疗宠物、服务性动物和临床前研究对象引起了人们对治疗后与动物互动的人员安全的担忧。本研究考虑了狗骨骼疾病的三种治疗方法：Sm-1,4,7,10-四氮杂十二烷四亚甲基膦酸，这是一种寻骨放射性药物；未封装的 Y 形永久性间质植入物，有时称为“液体近距离放射治疗”； Sn 放射滑膜切除术，也称为放射滑膜切除术。分析了 Sm 和 Sn 处理的外部暴露率读数，以及 1 m 距离处 Sn 和所有三个与组织直接接触的蒙特卡罗模拟的剂量。从外部暴露的角度来看，接受过任何这些通常进行的活动治疗的狗可以在治疗后立即解除辐射安全隔离。在 Y 间质植入后三周内或 Sn 放射滑膜移植后一个月内，人们应避免长时间近距离接触，例如与接受治疗的狗睡觉。用Sm-1,4,7,10-四氮杂十二烷四亚甲基膦酸处理后无需避免这种情况。