Currently, conjunctivitis is treated using ofloxacin eye drop solution, which shows low bioavailability and patient non-compliance. Ofloxacin loaded contact lens can be used to overcome the issues related to eye drop solutions (i.e. low bioavailability and frequent instillation). However, the conventional soaking method shows poor ofloxacin uptake and significantly affect the swelling and optical properties of the contact lenses. The current research investigates the effect of microemulsion on the ofloxacin uptake and its effect on the physical properties of the contact lens along with ofloxacin-release kinetics. In comparison to the conventional soaking method (Of-SM, ofloxacin-packaging solution), the ofloxacin loaded microemulsion-soaked contact lenses (Of-ME) showed improved drug uptake and physical properties of the contact lenses. The in vitro release data of Of-ME contact lenses showed 72–120 h release profile, while Of-SM contact lenses showed 24–60 h. The in vivo drug release data in the tear fluid (New Zealand rabbit’s eye) showed high ofloxacin retention in comparison to the eye drop solution. The efficacy study in the rabbit model showed equivalent healing effect with the Of-ME contact lens in comparison to the frequent high dose eye drop therapy. Thus, the study demonstrates the application of microemulsion system to improve the ofloxacin loading capacity in the contact lens along with improvement in the physical properties to treat conjunctivitis.

目前，结膜炎使用氧氟沙星滴眼液治疗，其生物利​​用度低且患者不依从。含氧氟沙星的隐形眼镜可用于克服与滴眼液相关的问题（即生物利用度低和频繁滴注）。然而，传统的浸泡方法显示出对氧氟沙星的吸收较差并且显着影响隐形眼镜的溶胀和光学性能。目前的研究调查了微乳液对氧氟沙星摄取的影响及其对隐形眼镜物理特性的影响以及氧氟沙星释放动力学。与传统的浸泡方法（Of-SM，氧氟沙星包装溶液）相比，载有氧氟沙星的微乳液浸泡隐形眼镜 (Of-ME) 显示出隐形眼镜的药物吸收和物理特性有所改善。这Of-ME 隐形眼镜的体外释放数据显示 72-120 小时的释放曲线，而 Of-SM 隐形眼镜则显示 24-60 小时。在体内在泪液（新西兰兔的眼睛）的药物释放数据相比，所述滴眼剂溶液表现出较高的氧氟沙星保留。兔模型中的疗效研究显示，与频繁的高剂量滴眼液疗法相比，Of-ME 隐形眼镜具有相同的愈合效果。因此，该研究证明了应用微乳液系统来提高隐形眼镜中氧氟沙星的负载能力以及改善治疗结膜炎的物理特性。