Layered osteochondral composite scaffolds are considered as a promising strategy for the treatment of osteochondral defects. However, the insufficient osseous support and integration of the subchondral bone layer frequently result in the failure of osteochondral repair. Therefore, it is essentially important to explore new subchondral bone constructs tailored to support bone integration and healing. In this study, a novel three-dimensional porous biomimetic construct (HA/pDA-OTMS) was successfully developed by polydopamine (pDA) regulating hydroxyapatite (HA) microspheres grown in the honeycomb-like mollusk shell-derived organic template (OTMS). The biomimetic OTMS had good mechanical properties, high toughness, biodegradability and excellent biocompatibility. Moreover, the long-range ordered cavity structure of OTMS allowed the smallest material to create the largest and most stable geometric space, endowing it high HA loading capacity. The modification of pDA on OTMS surface e...

中文翻译：

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聚多巴胺调节羟基磷灰石微球生长在三维蜂窝状软体动物壳衍生的有机模板中，用于成骨。

分层的骨软骨复合支架被认为是治疗骨软骨缺损的一种有前途的策略。然而，软骨下骨层的骨支撑和整合不足常常导致骨软骨修复失败。因此，探索专门为支持骨整合和愈合而设计的新的软骨下骨构造至关重要。在这项研究中，新型的三维多孔仿生构造（HA / pDA-OTMS）是由聚多巴胺（pDA）调节在蜂窝状软体动物壳衍生的有机模板（OTMS）中生长的羟基磷灰石（HA）微球成功开发的。仿生OTMS具有良好的机械性能，高韧性，可生物降解性和优异的生物相容性。此外，OTMS的远程有序空腔结构允许最小的材料创建最大和最稳定的几何空间，从而赋予其高HA承载能力。OTMS表面上pDA的修饰...