Increasing evidence has announced the emerging roles of long noncoding RNAs (lncRNAs) in modulating bone homeostasis due to their potential regulating effects on bone-related cells' proliferation, migration, differentiation and apoptosis. Thus, lncRNAs have been considered as a promising gene tool to facilitate the bone regeneration process and then to predict and cure bone-related diseases such as osteosarcoma, osteoporosis, and osteoarthritis. In this review, we first enumerated several kinds of dysregulated lncRNAs and concisely summarized their regulating role in bone formation as well as resorption process. The related mechanisms were also discussed, respectively. Then, the positive or negative behavior of these lncRNAs in bone-related diseases was elucidated. This review provides an in-depth sight about the lncRNA's clinical values and limitations, which is conducive to explore new gene targets and further establish new therapeutic strategies for bone-related disease.

中文翻译：

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长非编码RNA在骨骼稳态中的新兴作用及其在骨相关疾病中的潜在应用。

越来越多的证据表明，长非编码RNA（lncRNA）在调节骨稳态中起着新兴作用，因为它们对骨相关细胞的增殖，迁移，分化和凋亡具有潜在的调节作用。因此，lncRNA被认为是促进骨再生过程，然后预测和治愈与骨相关的疾病（如骨肉瘤，骨质疏松和骨关节炎）的有前途的基因工具。在这篇综述中，我们首先列举了几种失调的lncRNA，并简要总结了它们在骨形成以及吸收过程中的调控作用。还分别讨论了相关的机制。然后，阐明了这些lncRNA在骨骼相关疾病中的阳性或阴性行为。这篇评论深入了解了lncRNA'