Abstract

The present study was aimed at the assessment of effects of anxiolytic Selank and nootropic Semax on the whole-brain resting-state functional connectivity (FC) of each of the predefined regions of interest (ROIs) in 52 healthy participants. The ROIs included amygdala (one of the key regions for the regulation of anxiety) and dorsolateral prefrontal cortex (DLPFC; the key region for executive functions, including working memory) in the right and left hemisphere. Resting-state fMRI was carried out three times, namely before, after 5 and 20 min of the injection of either Semax, or Selank, or placebo. Between-group alongwith between-condition differences were revealed in FC between the right amygdala and a region in fusiform, inferior and middle temporal as well as parahippocampal gyri in the right hemisphere. Post hoc analysis allowed us to define both general and specific effects of Selank and Semax on FC between the right amygdala and the right temporal cortex for the first time.

中文翻译：

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功能联结组学方法研究Selank和Semax效应。

摘要

本研究旨在评估抗焦虑Selank和促智Semax对52位健康参与者的每个预定关注区域（ROI）的全脑静止状态功能连接（FC）的影响。ROI包括左右半球的杏仁核（调节焦虑的关键区域之一）和背外侧前额叶皮层（DLPFC；执行功能的关键区域，包括工作记忆）。静息状态功能磁共振成像进行了3次，即在注射Semax，Selank或安慰剂之前5、20分钟之前，之后。右杏仁核与右半球梭状，下中中颞以及海马旁回旋区之间的FC显示组间以及条件间差异。